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Literature DB >> 19176514

Grab your partner with both hands: cytoskeletal remodeling by Arp2/3 signaling.

Abstract

The seemingly simple structure of the actin filament belies the elaborate signaling pathways that regulate its assembly and disassembly in eukaryotic cells. In retrospect, this signaling complexity should not be surprising. Actin regulates many dynamic cellular processes, including protein and organelle trafficking, establishment of cell polarity, directional migration, cellular traction, and the efficiency of endocytosis. Signaling events that coordinately control actin turnover during these processes must display a high degree of sophistication. Emerging data on an important regulator of actin dynamics, the actin-related protein 2 and 3 (Arp2/3) complex, suggest a model of how this may occur.

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Year: 2009 PMID： 19176514 PMCID： PMC2805900 DOI： 10.1126/scisignal.255pe5

Source DB: PubMed Journal: Sci Signal ISSN： 1945-0877 Impact factor: 8.192

36 in total

1. The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly.

Authors: R Rohatgi; L Ma; H Miki; M Lopez; T Kirchhausen; T Takenawa; M W Kirschner
Journal: Cell Date: 1999-04-16 Impact factor: 41.582

2. Actin polymerization is induced by Arp2/3 protein complex at the surface of Listeria monocytogenes.

Authors: M D Welch; A Iwamatsu; T J Mitchison
Journal: Nature Date: 1997-01-16 Impact factor: 49.962

3. Sequential interaction of actin-related proteins 2 and 3 (Arp2/3) complex with neural Wiscott-Aldrich syndrome protein (N-WASP) and cortactin during branched actin filament network formation.

Authors: Takehito Uruno; Jiali Liu; Yansong Li; Nicole Smith; Xi Zhan
Journal: J Biol Chem Date: 2003-05-05 Impact factor: 5.157

4. PtdIns(3,4,5)P3 binding is necessary for WAVE2-induced formation of lamellipodia.

Authors: Tsukasa Oikawa; Hideki Yamaguchi; Toshiki Itoh; Masayoshi Kato; Takeshi Ijuin; Daisuke Yamazaki; Shiro Suetsugu; Tadaomi Takenawa
Journal: Nat Cell Biol Date: 2004-04-25 Impact factor: 28.824

5. Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex.

Authors: L M Machesky; R H Insall
Journal: Curr Biol Date: 1998 Dec 17-31 Impact factor: 10.834

6. A conserved amphipathic helix in WASP/Scar proteins is essential for activation of Arp2/3 complex.

Authors: Sanjay C Panchal; Donald A Kaiser; Eduardo Torres; Thomas D Pollard; Michael K Rosen
Journal: Nat Struct Biol Date: 2003-08

7. Sra-1 and Nap1 link Rac to actin assembly driving lamellipodia formation.

Authors: Anika Steffen; Klemens Rottner; Julia Ehinger; Metello Innocenti; Giorgio Scita; Jürgen Wehland; Theresia E B Stradal
Journal: EMBO J Date: 2004-02-05 Impact factor: 11.598

8. Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck.

Authors: Sharon Eden; Rajat Rohatgi; Alexandre V Podtelejnikov; Matthias Mann; Marc W Kirschner
Journal: Nature Date: 2002-08-15 Impact factor: 49.962

9. Abi1 is essential for the formation and activation of a WAVE2 signalling complex.

Authors: Metello Innocenti; Adriana Zucconi; Andrea Disanza; Emanuela Frittoli; Liliana B Areces; Anika Steffen; Theresia E B Stradal; Pier Paolo Di Fiore; Marie-France Carlier; Giorgio Scita
Journal: Nat Cell Biol Date: 2004-03-28 Impact factor: 28.824

10. Activation of Arp2/3 complex: addition of the first subunit of the new filament by a WASP protein triggers rapid ATP hydrolysis on Arp2.

Authors: Mark J Dayel; R Dyche Mullins
Journal: PLoS Biol Date: 2004-04-13 Impact factor: 8.029

12 in total

1. Caenorhabditis elegans wsp-1 regulation of synaptic function at the neuromuscular junction.

Authors: Yuqian Zhang; Terrance J Kubiseski
Journal: J Biol Chem Date: 2010-05-25 Impact factor: 5.157

2. Pro-prion binds filamin A, facilitating its interaction with integrin beta1, and contributes to melanomagenesis.

Authors: Chaoyang Li; Shuiliang Yu; Fumihiko Nakamura; Olli T Pentikäinen; Neena Singh; Shaoman Yin; Wei Xin; Man-Sun Sy
Journal: J Biol Chem Date: 2010-07-21 Impact factor: 5.157

3. Bi-modal regulation of a formin by srGAP2.

Authors: Frank M Mason; Ernest G Heimsath; Henry N Higgs; Scott H Soderling
Journal: J Biol Chem Date: 2010-12-09 Impact factor: 5.157

Review 4. Integrin signalling adaptors: not only figurants in the cancer story.

Authors: Sara Cabodi; Maria del Pilar Camacho-Leal; Paola Di Stefano; Paola Defilippi
Journal: Nat Rev Cancer Date: 2010-11-24 Impact factor: 60.716

5. miR-195 regulates intestinal epithelial restitution after wounding by altering actin-related protein-2 translation.

Authors: Shelley R Wang; Navneeta Rathor; Min S Kwon; Lan Xiao; Hee Kyoung Chung; Douglas J Turner; Jian-Ying Wang; Jaladanki N Rao
Journal: Am J Physiol Cell Physiol Date: 2022-03-02 Impact factor: 4.249

Review 6. Immune pathology associated with altered actin cytoskeleton regulation.

Authors: Dilki C Wickramarachchi; Argyrios N Theofilopoulos; Dwight H Kono
Journal: Autoimmunity Date: 2010-02 Impact factor: 2.815

7. Arp2/3 complex inhibitors adversely affect actin cytoskeleton remodeling in the cultured murine kidney collecting duct M-1 cells.

Authors: Daria V Ilatovskaya; Vladislav Chubinskiy-Nadezhdin; Tengis S Pavlov; Leonid S Shuyskiy; Viktor Tomilin; Oleg Palygin; Alexander Staruschenko; Yuri A Negulyaev
Journal: Cell Tissue Res Date: 2013-09-15 Impact factor: 5.249