| Literature DB >> 1917516 |
A Harrison1, C A Walker, D Parker, K J Jankowski, J P Cox, A S Craig, J M Sansom, N R Beeley, R A Boyce, L Chaplin.
Abstract
Yttrium binding ligands DOTA, caDTPA and CT-DTPA were each conjugated to monoclonal antibody B72.3, labelled with 90Y and injected into mice in order to assess the in vivo inertness of the antibody-linked 90Y-ligand complexes. Levels of 90Y in femur shafts of the DOTA-B72.3 mice were low, being approximately 7 and 44%, respectively, of levels in the femur shafts of the caDTPA-B72.3 and CT-DTPA-B72.3 treated mice. This finding demonstrates the greater inertness and by implication the greater suitability for immunotherapy of the DOTA-90Y complex.Entities:
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Year: 1991 PMID： 1917516 DOI： 10.1016/0883-2897(91)90107-v
Source DB: PubMed Journal: Int J Rad Appl Instrum B ISSN： 0883-2897