Literature DB >> 1917429

Thromboblastic hyperthyroidism: sensitive monoclonal TSH assay demonstrates suppressed immunoreactive TSH.

B Abuaisha1, E Barrett, J O'Hare.   

Abstract

We describe a case of frank clinical hyperthyroidism due to hydatidiform mole. This is thought to be due to human chorionic gonadotrophin (hCG) or a closely related molecule produced by the tumour. hCG can cross-react with TSH in older TSH radioimmunoassays causing falsely elevated TSH levels. We demonstrate this does not occur with a chemiluminescent immunometric (monoclonal) TSH assay despite circulating hCG levels greater than 10(6) u/L.

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Year:  1991        PMID： 1917429     DOI： 10.1007/bf02947265

Source DB:  PubMed          Journal:  Ir J Med Sci        ISSN： 0021-1265            Impact factor:   1.568


  6 in total

1.  Increased thyroid function without clinical hyperthyroidism in patients with choriocarcinoma.

Authors:  W D ODELL; R W BATES; R S RIVLIN; M B LIPSETT; R HERTZ
Journal:  J Clin Endocrinol Metab       Date:  1963-07       Impact factor: 5.958

2.  Thyroid function in trophoblastic disease.

Authors:  M Lemon; B R Bevan; T C Li; G W Pennington
Journal:  Br J Obstet Gynaecol       Date:  1987-11

3.  Assessment of an enhanced chemiluminescent immunometric assay for TSH in 1127 patients.

Authors:  C R Squire; T M Gimlette
Journal:  Ann Clin Biochem       Date:  1987-07       Impact factor: 2.057

4.  Hydatidiform mole--a cause of clinical hyperthyroidism. Report of two cases with evidence that the molar tissue secreted a thyroid stimulator.

Authors:  J M Hershman; H P Higgins
Journal:  N Engl J Med       Date:  1971-03-18       Impact factor: 91.245

5.  Human chorionic gonadotropin stimulates iodide uptake, adenylate cyclase, and deoxyribonucleic acid synthesis in cultured rat thyroid cells.

Authors:  J M Hershman; H Y Lee; M Sugawara; C J Mirell; X P Pang; M Yanagisawa; A E Pekary
Journal:  J Clin Endocrinol Metab       Date:  1988-07       Impact factor: 5.958

6.  Components of the total serum thyroid hormone concentrations during pregnancy: high free thyroxine and blunted thyrotropin (TSH) response to TSH-releasing hormone in the first trimester.

Authors:  J Guillaume; G C Schussler; J Goldman
Journal:  J Clin Endocrinol Metab       Date:  1985-04       Impact factor: 5.958
  6 in total

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