Septicemia and meningitis in the newborn calf.

Neonatal infections and sepsis occur most frequently in calves with failure of passive transfer. If the invading bacteria are not rapidly controlled, they can set up focal infections, such as in growth plates, joints, or meninges, or generalized sepsis may occur. If not successfully treated, sepsis can lead to a systemic inflammatory response, multiple organ dysfunction syndromes, septic shock, and death. Treatments are based on selecting an appropriate antimicrobial drug and dosage, supportive therapy, fluid therapy, nonsteroidal anti-inflammatory drugs, and plasma transfusion. Preventing the failure of passive transfer through good colostrum management is essential.