Literature DB >> 19172581

Antihyperlipidemic compounds from the fruit of Piper longum L.

Zhuang Jin1, Gereltu Borjihan, Ruiguo Zhao, Zhaorigetu Sun, Gerald B Hammond, Toshiyuki Uryu.   

Abstract

A bioassay-guided isolation of an ethanol extract of the fruit of Piper longum L. yielded piperlonguminine, piperine and pipernonaline, as the main antihyperlipidemic constituents. They exhibit appreciable antihyperlipidemic activity in vivo, which is comparable to that of the commercial antihyperlipidemic drug, simvastatin. Copyright 2009 John Wiley & Sons, Ltd.

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Year:  2009        PMID： 19172581     DOI： 10.1002/ptr.2630

Source DB:  PubMed          Journal:  Phytother Res        ISSN： 0951-418X            Impact factor:   5.878


  9 in total

1.  Piperlonguminine downregulates endothelial protein C receptor shedding in vitro and in vivo.

Authors:  Sae-Kwang Ku; Jeong Ah Kim; Jong-Sup Bae
Journal:  Inflammation       Date:  2014-04       Impact factor: 4.092

2.  Piperlongumine inhibits proliferation and survival of Burkitt lymphoma in vitro.

Authors:  Seong-Su Han; Dong-Ju Son; Hwakyung Yun; Natalie L Kamberos; Siegfried Janz
Journal:  Leuk Res       Date:  2012-12-10       Impact factor: 3.156

3.  Occurrence of piperidine alkaloids in Piper species collected in different areas.

Authors:  Narisu Bao; Sarangowa Ochir; Zhaorigetu Sun; Gereltu Borjihan; Takashi Yamagishi
Journal:  J Nat Med       Date:  2013-04-27       Impact factor: 2.343

4.  Vascular barrier protective effects of piperlonguminine in vitro and in vivo.

Authors:  Sae-Kwang Ku; Jeong Ah Kim; Jong-Sup Bae
Journal:  Inflamm Res       Date:  2014-01-29       Impact factor: 4.575

5.  The synthetic antihyperlipidemic drug potassium piperate selectively kills breast cancer cells through inhibiting G1-S-phase transition and inducing apoptosis.

Authors:  Lifei Fan; Xuemin Cao; Huijuan Yan; Qian Wang; Xiaoxia Tian; Lan Zhang; Xiaoyan He; Gereltu Borjihan
Journal:  Oncotarget       Date:  2017-07-18

6.  Anticoagulant activities of piperlonguminine in vitro and in vivo.

Authors:  Wonhwa Lee; Hayoung Yoo; Sae-Kwang Ku; Jeong Ah Kim; Jong-Sup Bae
Journal:  BMB Rep       Date:  2013-10       Impact factor: 4.778

7.  Piperlongumine Blocks JAK2-STAT3 to Inhibit Collagen-Induced Platelet Reactivity Independent of Reactive Oxygen Species.

Authors:  Hengjie Yuan; Katie L Houck; Ye Tian; Uddalak Bharadwaj; Ken Hull; Zhou Zhou; Mingzhao Zhu; Mingzhao Zhou; Xiaoping Wu; David J Tweardy; Daniel Romo; Xiaoyun Fu; Yanjun Zhang; Jianning Zhang; Jing-fei Dong
Journal:  PLoS One       Date:  2015-12-08       Impact factor: 3.240

8.  Small-molecule inhibition of STAT3 in radioresistant head and neck squamous cell carcinoma.

Authors:  Uddalak Bharadwaj; T Kris Eckols; Xuejun Xu; Moses M Kasembeli; Yunyun Chen; Makoto Adachi; Yongcheng Song; Qianxing Mo; Stephen Y Lai; David J Tweardy
Journal:  Oncotarget       Date:  2016-05-03

9.  Piperlongumine Inhibits Titanium Particles-Induced Osteolysis, Osteoclast Formation, and RANKL-Induced Signaling Pathways.

Authors:  Xuan Liu; Li Diao; Yudie Zhang; Xue Yang; Junnan Zhou; Yuhang Mao; Xiaotian Shi; Fuli Zhao; Mei Liu
Journal:  Int J Mol Sci       Date:  2022-03-05       Impact factor: 5.923
  9 in total

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