Literature DB >> 19171483

Time-dependent inactivation of human phenylethanolamine N-methyltransferase by 7-isothiocyanatotetrahydroisoquinoline.

Qian Wu1, Joanne M Caine, Stuart A Thomson, Meri Slavica, Gary L Grunewald, Michael J McLeish.   

Abstract

Inhibitors of phenylethanolamine N-methyltransferase [PNMT, the enzyme that catalyzes the final step in the biosynthesis of epinephrine (Epi)] may be of use in determining the role of Epi in the central nervous system. Here we describe the synthesis and characterization of 7-SCN tetrahydroisoquinoline as an affinity label for human PNMT.

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Year:  2009        PMID： 19171483      PMCID： PMC2696812          DOI： 10.1016/j.bmcl.2009.01.014

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  31 in total

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Authors:  R G Langdon
Journal:  Methods Enzymol       Date:  1977       Impact factor: 1.600

2.  Inhibition of human cytochrome P450 enzymes by 1,2-dithiole-3-thione, oltipraz and its derivatives, and sulforaphane.

Authors:  S Langouët; L L Furge; N Kerriguy; K Nakamura; A Guillouzo; F P Guengerich
Journal:  Chem Res Toxicol       Date:  2000-04       Impact factor: 3.739

3.  Evidence for adrenaline neurons in the rat brain.

Authors:  T Hökfelt; K Fuxe; M Goldstein; O Johansson
Journal:  Acta Physiol Scand       Date:  1973-10

4.  Structural, mutagenic, and kinetic analysis of the binding of substrates and inhibitors of human phenylethanolamine N-methyltransferase.

Authors:  Qian Wu; Christine L Gee; Frank Lin; Joel D Tyndall; Jennifer L Martin; Gary L Grunewald; Michael J McLeish
Journal:  J Med Chem       Date:  2005-11-17       Impact factor: 7.446

5.  Mutagenesis and mechanism-based inhibition of Streptococcus pyogenes Glu-tRNAGln amidotransferase implicate a serine-based glutaminase site.

Authors:  Mark R Harpel; Kurumi Y Horiuchi; Ying Luo; Li Shen; Wenjun Jiang; David J Nelson; Kelley C Rogers; Carl P Decicco; Robert A Copeland
Journal:  Biochemistry       Date:  2002-05-21       Impact factor: 3.162

6.  Getting the adrenaline going: crystal structure of the adrenaline-synthesizing enzyme PNMT.

Authors:  J L Martin; J Begun; M J McLeish; J M Caine; G L Grunewald
Journal:  Structure       Date:  2001-10       Impact factor: 5.006

7.  Evidence for the involvement of central epinephrine systems in the regulation of luteinizing hormone, prolactin, and growth hormone release in female rats.

Authors:  W R Crowley; L C Terry; M D Johnson
Journal:  Endocrinology       Date:  1982-04       Impact factor: 4.736

8.  The kinetics of reversible tight-binding inhibition.

Authors:  J W Williams; J F Morrison
Journal:  Methods Enzymol       Date:  1979       Impact factor: 1.600

9.  Inhibition and inactivation of human cytochrome P450 isoforms by phenethyl isothiocyanate.

Authors:  M Nakajima; R Yoshida; N Shimada; H Yamazaki; T Yokoi
Journal:  Drug Metab Dispos       Date:  2001-08       Impact factor: 3.922

10.  Blood pressure response to central and/or peripheral inhibition of phenylethanolamine N-methyltransferase in normotensive and hypertensive rats.

Authors:  J Black; B Waeber; M R Bresnahan; I Gavras; H Gavras
Journal:  Circ Res       Date:  1981-08       Impact factor: 17.367
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  1 in total

1.  Kinetic and pH studies on human phenylethanolamine N-methyltransferase.

Authors:  Qian Wu; Michael J McLeish
Journal:  Arch Biochem Biophys       Date:  2013-09-07       Impact factor: 4.013
  1 in total

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