| Literature DB >> 19170680 |
Philip A Beer1, Amy V Jones, Anthony J Bench, Andrea Goday-Fernandez, Elaine M Boyd, Krishna J Vaghela, Wendy N Erber, Bassam Odeh, Christine Wright, Mary Frances McMullin, Jonathan Cullis, Brian J P Huntly, Claire N Harrison, Nicholas C P Cross, Anthony R Green.
Abstract
This study looked for clonal diversity in patients with a myeloproliferative neoplasm associated with more than one acquired genetic lesion. A tyrosine kinase mutation and a cytogenetic lesion were present in the same clone in six of seven patients. By contrast, the genetic lesions were present in separate clones in all six patients with two tyrosine kinase pathway mutations. Moreover, in two patients the clones were genetically unrelated by X-chromosome inactivation studies. These data demonstrated clonal diversity in a subset of patients with early stage haematopoietic malignancy and showed, for the first time, that such clones may arise independently.Entities:
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Year: 2009 PMID： 19170680 DOI： 10.1111/j.1365-2141.2008.07560.x
Source DB: PubMed Journal: Br J Haematol ISSN： 0007-1048 Impact factor: 6.998