| Literature DB >> 19170571 |
J S Shane Rountree1, Paul V Murphy.
Abstract
The facile preparation of a novel 8-membered polyhydroxylated salicylic acid lactone from 2,6-dihydroxybenzoic acid and sodium thio-D-glucose is described. The key step involved a sodium hydride promoted intramolecular lactonization in the presence of excess TMSCl, which led to isolation of the "natural product like" lactone.Entities:
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Year: 2009 PMID： 19170571 DOI： 10.1021/ol802852r
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005