| Literature DB >> 19170565 |
Hegui Gong1, R Stephen Andrews, Joseph L Zuccarello, Stephen J Lee, Michel R Gagné.
Abstract
A mild, stereoselective method for the Ni-catalyzed synthesis of alpha-C-alkylglycosides is reported. This approach entails the reductive coupling of glycosyl bromides with activated alkenes at room temperature, with low alkene loading as an important feature. Diastereoselective coupling with 2-substituted acrylate derivatives was made possible through the use of 2,4-dimethyl-3-pentanol as a proton source.Entities:
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Year: 2009 PMID： 19170565 DOI： 10.1021/ol8028737
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005