Literature DB >> 1917048

Preliminary characterization of Borrelia burgdorferi CSF isolates.

G Khanakah1, M M Millner, R R Müllegger, G Stanek.   

Abstract

Borrelia burgdorferi was cultivated from three cerebrospinal fluid (CSF) samples of children (aged three and a half, four and a half and eight years) who were admitted to the hospital because of acute facial palsy, aseptic meningitis, and aseptic meningitis plus facial palsy. CSF was taken on day one in two cases and on day two in the remaining case after onset of symptoms. All three strains showed a very similar SDS-PAGE pattern, without an OspB and 20kD band. However, of nine monoclonal antibodies (Moab) raised against B. burgdorferi B31, the Moab H5332 recognized two strains, one of them very weakly, and the flagella specific Moabs H9724, H605, and H6TS (less intensively) recognized all strains. This preliminary characterization reveals heterogeneity among CSF Borrelia isolates of cases from a very close geographic area.

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Year:  1991        PMID： 1917048     DOI： 10.1007/bf01644969

Source DB:  PubMed          Journal:  Infection        ISSN： 0300-8126            Impact factor:   3.553


  7 in total

1.  Heterogeneity of major proteins in Lyme disease borreliae: a molecular analysis of North American and European isolates.

Authors:  A G Barbour; R A Heiland; T R Howe
Journal:  J Infect Dis       Date:  1985-09       Impact factor: 5.226

2.  Plasmid analysis and restriction fragment length polymorphisms of chromosomal DNA allow a distinction between Borrelia burgdorferi strains.

Authors:  M Stålhammar-Carlemalm; E Jenny; L Gern; A Aeschlimann; J Meyer
Journal:  Zentralbl Bakteriol       Date:  1990-10

3.  Antigenic variability of Borrelia burgdorferi.

Authors:  B Wilske; V Preac-Mursic; G Schierz; R Kühbeck; A G Barbour; M Kramer
Journal:  Ann N Y Acad Sci       Date:  1988       Impact factor: 5.691

4.  Lyme disease spirochetes and ixodid tick spirochetes share a common surface antigenic determinant defined by a monoclonal antibody.

Authors:  A G Barbour; S L Tessier; W J Todd
Journal:  Infect Immun       Date:  1983-08       Impact factor: 3.441

5.  Reactivity of European and American isolates of Borrelia burgdorferi with different monoclonal antibodies by means of a microimmunoblot technique.

Authors:  G Stanek; B Jurkowitsch; C Köchl; I Burger; G Khanakha
Journal:  Zentralbl Bakteriol       Date:  1990-04

6.  A Borrelia-specific monoclonal antibody binds to a flagellar epitope.

Authors:  A G Barbour; S F Hayes; R A Heiland; M E Schrumpf; S L Tessier
Journal:  Infect Immun       Date:  1986-05       Impact factor: 3.441

7.  Isolation and cultivation of Lyme disease spirochetes.

Authors:  A G Barbour
Journal:  Yale J Biol Med       Date:  1984 Jul-Aug
  7 in total
  1 in total

1.  Genotypic and phenotypic analysis of Borrelia burgdorferi isolates from The Netherlands.

Authors:  L M Nohlmans; R de Boer; A E van den Bogaard; C P van Boven
Journal:  J Clin Microbiol       Date:  1995-01       Impact factor: 5.948
  1 in total

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