BACKGROUND: Cardiopulmonary bypass is known to affect cytokine release leading to a generalized endogenous immune reaction similar to that described in sepsis, without having been explored in great detail. Therefore we evaluated the anti- and pro-inflammatory cytokine responses after heart surgery. METHODS: 16 patients who underwent coronary artery bypass graft (CABG) surgery with extracorporeal circulation were included. ST2, IL-4 and IL-10 served as markers for TH2 cytokine response; IL-6, IL-8 and IFN-gamma as TH1 markers. Furthermore, total immunoglobulin subtype analysis (IgM, IgG, IgE) was performed. RESULTS: Serum levels of soluble ST2 started to climb at 60 minutes (from 38 +/- 14 preoperatively to 1 480 +/- 890 pg/ml) and peaked 24 hours after surgery (13 360 +/- 2 840 pg/ml, P < 0.001). IL-10 reached a maximum at 60 minutes and returned to baseline levels 24 hours later. IL-6 and IL-8 levels peaked 60 minutes after surgery. IL-4 and IFN-gamma did not change. Only IgM showed a significant peak on day eight ( P < 0.001). CONCLUSION: Our results demonstrate that CABG surgery induces a massive long-lasting secretion of ST2, a protein related to immune suppression.
BACKGROUND: Cardiopulmonary bypass is known to affect cytokine release leading to a generalized endogenous immune reaction similar to that described in sepsis, without having been explored in great detail. Therefore we evaluated the anti- and pro-inflammatory cytokine responses after heart surgery. METHODS: 16 patients who underwent coronary artery bypass graft (CABG) surgery with extracorporeal circulation were included. ST2, IL-4 and IL-10 served as markers for TH2 cytokine response; IL-6, IL-8 and IFN-gamma as TH1 markers. Furthermore, total immunoglobulin subtype analysis (IgM, IgG, IgE) was performed. RESULTS: Serum levels of soluble ST2 started to climb at 60 minutes (from 38 +/- 14 preoperatively to 1 480 +/- 890 pg/ml) and peaked 24 hours after surgery (13 360 +/- 2 840 pg/ml, P < 0.001). IL-10 reached a maximum at 60 minutes and returned to baseline levels 24 hours later. IL-6 and IL-8 levels peaked 60 minutes after surgery. IL-4 and IFN-gamma did not change. Only IgM showed a significant peak on day eight ( P < 0.001). CONCLUSION: Our results demonstrate that CABG surgery induces a massive long-lasting secretion of ST2, a protein related to immune suppression.
Authors: Benjamin S Frank; Tracy T Urban; Karlise Lewis; Suhong Tong; Courtney Cassidy; Max B Mitchell; Christopher S Nichols; Jesse A Davidson Journal: Congenit Heart Dis Date: 2019-01-16 Impact factor: 2.007
Authors: Stefan Hacker; Christopher Lambers; Andreas Pollreisz; Konrad Hoetzenecker; Michael Lichtenauer; Andreas Mangold; Tina Niederpold; Andreas Hacker; György Lang; Martin Dworschak; Thomas Vukovich; Christopher Gerner; Walter Klepetko; Hendrik Jan Ankersmit Journal: J Clin Lab Anal Date: 2009 Impact factor: 2.352
Authors: Yang Qiu; Qiao Chen; Wei Wu; Shixin Zhang; Meng Tang; Ya Chen; Chao Zhang; Ni Zhou; Nan Jiang; Jianping Feng; Mei Xia; Haidong Wang Journal: Thorac Cancer Date: 2019-02-19 Impact factor: 3.500
Authors: Cecilia Veraar; Stefan Schwarz; Jürgen Thanner; Martin Direder; Panja M Boehm; Leopold Harnoncourt; Joachim Ortmayr; Clarence Veraar; Julia Mascherbauer; Walter Klepetko; Martin Dworschak; Hendrik J Ankersmit; Bernhard Moser Journal: Ann Transl Med Date: 2021-03
Authors: Tina E Faber; Annemieke Schuurhof; Annelies Vonk; Gerard H Koppelman; Marije P Hennus; Jan L L Kimpen; Riny Janssen; Louis J Bont Journal: PLoS One Date: 2012-05-04 Impact factor: 3.240