Literature DB >> 19169826

An implantable MEMS drug delivery device for rapid delivery in ambulatory emergency care.

N M Elman1, H L Ho Duc, M J Cima.   

Abstract

We introduce the first implantable drug delivery system based on MEMS (Micro-Electro-Mechanical-Systems) technology specifically designed as a platform for treatment in ambulatory emergency care. The device is named IRD(3) (implantable rapid drug delivery device) and allows rapid delivery of drugs. Vasopressin was used as a model drug for in vitro tests as it is a commonly used drug for cardiac resuscitation. Experimental results reveal that the IRD(3) provides an effective method for rapid delivery without significant drug degradation. Several medical uses and delivery modalities for IRD(3) are proposed.

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Year:  2009        PMID： 19169826     DOI： 10.1007/s10544-008-9272-6

Source DB:  PubMed          Journal:  Biomed Microdevices        ISSN： 1387-2176            Impact factor:   2.838


  18 in total

1.  Intracranial MEMS based temozolomide delivery in a 9L rat gliosarcoma model.

Authors:  Byron C Masi; Betty M Tyler; Hansen Bow; Robert T Wicks; Yuan Xue; Henry Brem; Robert Langer; Michael J Cima
Journal:  Biomaterials       Date:  2012-05-14       Impact factor: 12.479

Review 2.  Enabling individualized therapy through nanotechnology.

Authors:  Jason H Sakamoto; Anne L van de Ven; Biana Godin; Elvin Blanco; Rita E Serda; Alessandro Grattoni; Arturas Ziemys; Ali Bouamrani; Tony Hu; Shivakumar I Ranganathan; Enrica De Rosa; Jonathan O Martinez; Christine A Smid; Rachel M Buchanan; Sei-Young Lee; Srimeenakshi Srinivasan; Matthew Landry; Anne Meyn; Ennio Tasciotti; Xuewu Liu; Paolo Decuzzi; Mauro Ferrari
Journal:  Pharmacol Res       Date:  2010-01-05       Impact factor: 7.658

3.  Implantable multireservoir device with stimulus-responsive membrane for on-demand and pulsatile delivery of growth hormone.

Authors:  Seung Ho Lee; Huiyan Piao; Yong Chan Cho; Se-Na Kim; Goeun Choi; Cho Rim Kim; Han Bi Ji; Chun Gwon Park; Cheol Lee; Chong In Shin; Won-Gun Koh; Young Bin Choy; Jin-Ho Choy
Journal:  Proc Natl Acad Sci U S A       Date:  2019-05-23       Impact factor: 11.205

4.  Simple minimally-invasive automatic antidote delivery device (A2D2) towards closed-loop reversal of opioid overdose.

Authors:  Bahar Dhowan; Jongcheon Lim; Michael D MacLean; Alycia G Berman; Min Ku Kim; Qi Yang; Jacqueline Linnes; Chi Hwan Lee; Craig J Goergen; Hyowon Lee
Journal:  J Control Release       Date:  2019-05-31       Impact factor: 9.776

5.  Nitinol actuated soft structures towards transnasal drug delivery: a pilot cadaver study.

Authors:  Manivannan Sivaperuman Kalairaj; Bok Seng Yeow; Chwee Ming Lim; Hongliang Ren
Journal:  Med Biol Eng Comput       Date:  2020-01-11       Impact factor: 2.602

6.  Bubble-free and pulse-free fluid delivery into microfluidic devices.

Authors:  Yang Jun Kang; Eunseop Yeom; Eunseok Seo; Sang-Joon Lee
Journal:  Biomicrofluidics       Date:  2014-01-29       Impact factor: 2.800

7.  Additive manufacturing of hydrogel-based materials for next-generation implantable medical devices.

Authors:  Sau Yin Chin; Yukkee Cheung Poh; Anne-Céline Kohler; Jocelyn T Compton; Lauren L Hsu; Kathryn M Lau; Sohyun Kim; Benjamin W Lee; Francis Y Lee; Samuel K Sia
Journal:  Sci Robot       Date:  2017-01-18

Review 8.  Reservoir-based drug delivery systems utilizing microtechnology.

Authors:  Cynthia L Stevenson; John T Santini; Robert Langer
Journal:  Adv Drug Deliv Rev       Date:  2012-02-21       Impact factor: 15.470

Review 9.  Micro- and nano-fabricated implantable drug-delivery systems.

Authors:  Ellis Meng; Tuan Hoang
Journal:  Ther Deliv       Date:  2012-12

10.  An Additive Manufacturing Technique for the Facile and Rapid Fabrication of Hydrogel-based Micromachines with Magnetically Responsive Components.

Authors:  Sau Yin Chin; Yukkee Cheung Poh; Anne-Céline Kohler; Samuel K Sia
Journal:  J Vis Exp       Date:  2018-07-18       Impact factor: 1.355
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