Literature DB >> 19169150

Acetaminophen hepatotoxicity and acute liver failure.

Linda J Chun1, Myron J Tong, Ronald W Busuttil, Jonathan R Hiatt.   

Abstract

Acetaminophen-induced hepatotoxicity is a common consequence of acetaminophen overdose and may lead to acute liver failure (ALF). Currently acetaminophen is the most common cause of ALF in both United States and United Kingdom, with a trend to increasing incidence in the United States. N-acetylcysteine is the most effective drug to prevent progression to liver failure with acetaminophen hepatotoxicity. Liver transplantation is the only definitive therapy that will significantly increase the chances of survival for advanced ALF. This communication reviews current information regarding causes and management of acetaminophen-induced hepatotoxicity and ALF.

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Year:  2009        PMID： 19169150     DOI： 10.1097/MCG.0b013e31818a3854

Source DB:  PubMed          Journal:  J Clin Gastroenterol        ISSN： 0192-0790            Impact factor:   3.062


  74 in total

1.  Acetaminophen overdose in children.

Authors:  Jacqueline D Ogilvie; Michael J Rieder; Rodrick Lim
Journal:  CMAJ       Date:  2012-06-04       Impact factor: 8.262

Review 2.  Molecular mechanisms underlying chemical liver injury.

Authors:  Xinsheng Gu; Jose E Manautou
Journal:  Expert Rev Mol Med       Date:  2012-02-03       Impact factor: 5.600

3.  Proteomic analysis of acetaminophen-induced hepatotoxicity and identification of heme oxygenase 1 as a potential plasma biomarker of liver injury.

Authors:  Yuan Gao; Zhijun Cao; Xi Yang; Mohamed A Abdelmegeed; Jinchun Sun; Si Chen; Richard D Beger; Kelly Davis; William F Salminen; Byoung-Joon Song; Donna L Mendrick; Li-Rong Yu
Journal:  Proteomics Clin Appl       Date:  2016-10-28       Impact factor: 3.494

4.  Prescription-acquired acetaminophen use and potential overuse patterns: 2001-2008.

Authors:  Mugdha Gokhale; Bradley C Martin
Journal:  Pharmacoepidemiol Drug Saf       Date:  2011-09-13       Impact factor: 2.890

5.  TRPM2 channels mediate acetaminophen-induced liver damage.

Authors:  Ehsan Kheradpezhouh; Linlin Ma; Arthur Morphett; Greg J Barritt; Grigori Y Rychkov
Journal:  Proc Natl Acad Sci U S A       Date:  2014-02-03       Impact factor: 11.205

6.  miRNA-324, a potential therapeutic target for paracetamol-induced liver injury.

Authors:  Hong Min Wu; Sang Geon Kim
Journal:  Stem Cell Investig       Date:  2016-10-25

Review 7.  Immune mechanisms in acetaminophen-induced acute liver failure.

Authors:  Oliver Krenkel; Jana C Mossanen; Frank Tacke
Journal:  Hepatobiliary Surg Nutr       Date:  2014-12       Impact factor: 7.293

8.  Dendritic cell depletion exacerbates acetaminophen hepatotoxicity.

Authors:  Michael K Connolly; Diego Ayo; Ashim Malhotra; Michael Hackman; Andrea S Bedrosian; Junaid Ibrahim; Napoleon E Cieza-Rubio; Andrew H Nguyen; Justin R Henning; Monica Dorvil-Castro; H Leon Pachter; George Miller
Journal:  Hepatology       Date:  2011-08-08       Impact factor: 17.425

9.  Activation of the farnesoid X receptor provides protection against acetaminophen-induced hepatic toxicity.

Authors:  Florence Ying Lee; Thomas Quad de Aguiar Vallim; Hansook Kim Chong; Yanqiao Zhang; Yaping Liu; Stacey A Jones; Timothy F Osborne; Peter A Edwards
Journal:  Mol Endocrinol       Date:  2010-06-23

10.  Characterizing the Effects of Race/Ethnicity on Acetaminophen Pharmacokinetics Using Physiologically Based Pharmacokinetic Modeling.

Authors:  Todd J Zurlinden; Brad Reisfeld
Journal:  Eur J Drug Metab Pharmacokinet       Date:  2017-02       Impact factor: 2.441
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