Literature DB >> 19168978

Viridicatumtoxin B, a new anti-MRSA agent from Penicillium sp. FR11.

Chang-Ji Zheng1, Hyung-Eun Yu, Eun-Hee Kim, Won-Gon Kim.   

Abstract

A new tetracycline-type antibiotic named viridicatumtoxin B along with the known compound viridicatumtoxin has been isolated from the mycelium of liquid fermentation cultures of Penicillium sp. FR11. The structure of viridicatumtoxin B was determined on the basis of MS and NMR data. Viridicatumtoxin B inhibited the growth of Staphylococcus aureus including methicillin-resistant S. aureus and quinolone-resistant S. aureus with MIC (microg/ml) of 0.5, which is similar with that of vancomycin, but 8-64 times higher activity than that of tetracycline.

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Year:  2008        PMID： 19168978     DOI： 10.1038/ja.2008.84

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  21 in total

1.  Identification of the viridicatumtoxin and griseofulvin gene clusters from Penicillium aethiopicum.

Authors:  Yit-Heng Chooi; Ralph Cacho; Yi Tang
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2.  AN483, a new anti-MRSA compound from Streptomyces sp.

Authors:  Yun J Kwon; Mi-Jin Sohn; Hiroyuki Koshino; Chang-Jin Kim; Won-Gon Kim
Journal:  J Antibiot (Tokyo)       Date:  2016-01-13       Impact factor: 2.649

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Review 4.  Cyclization of aromatic polyketides from bacteria and fungi.

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Journal:  Nat Prod Rep       Date:  2010-03-31       Impact factor: 13.423

Review 5.  Oxidative Cyclization in Natural Product Biosynthesis.

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Journal:  Chem Rev       Date:  2016-12-12       Impact factor: 60.622

6.  Inhibition of bacterial undecaprenyl pyrophosphate synthase by small fungal molecules.

Authors:  Junji Inokoshi; Yuichiro Nakamura; Saori Komada; Katsuichiro Komatsu; Hideaki Umeyama; Hiroshi Tomoda
Journal:  J Antibiot (Tokyo)       Date:  2016-04-06       Impact factor: 2.649

Review 7.  Natural Products as Platforms To Overcome Antibiotic Resistance.

Authors:  Sean E Rossiter; Madison H Fletcher; William M Wuest
Journal:  Chem Rev       Date:  2017-09-27       Impact factor: 60.622

Review 8.  A brief history of antibiotics and select advances in their synthesis.

Authors:  Kyriacos C Nicolaou; Stephan Rigol
Journal:  J Antibiot (Tokyo)       Date:  2017-07-05       Impact factor: 2.649

9.  Comparative characterization of fungal anthracenone and naphthacenedione biosynthetic pathways reveals an α-hydroxylation-dependent Claisen-like cyclization catalyzed by a dimanganese thioesterase.

Authors:  Yanran Li; Yit-Heng Chooi; Yuewei Sheng; Joan S Valentine; Yi Tang
Journal:  J Am Chem Soc       Date:  2011-09-14       Impact factor: 15.419

10.  Perspectives from nearly five decades of total synthesis of natural products and their analogues for biology and medicine.

Authors:  K C Nicolaou; Stephan Rigol
Journal:  Nat Prod Rep       Date:  2020-04-22       Impact factor: 13.423
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