Literature DB >> 19168975

Chaetomugilins, new selectively cytotoxic metabolites, produced by a marine fish-derived Chaetomium species.

Muroga Yasuhide1, Takeshi Yamada, Atsushi Numata, Reiko Tanaka.   

Abstract

Chaetomugilins A-F have been isolated from a strain of Chaetomium globosum originally isolated from the marine fish Mugil cephalus, and their absolute stereostructures have been elucidated on the basis of spectroscopic analyses, including 1D and 2D NMR techniques, some chemical transformations and an X-ray analysis. These compounds exhibited significant growth inhibition against cultured P388 cells and HL-60 cells. In addition, chaetomugilins A, C and F showed selective cytotoxic activities against 39 human cancer cell lines.

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Year:  2008        PMID： 19168975     DOI： 10.1038/ja.2008.81

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  18 in total

1.  Molecular epigenetic approach activates silent gene cluster producing dimeric bis-spiro-azaphilones in Chaetomium globosum CBS148.51.

Authors:  Meng-Hua Wang; Tao Jiang; Gang Ding; Shu-Bin Niu; Xue-Wei Wang; Meng Yu; Yu-Cheng Gu; Qiu-Bo Zhang; Jia-Huan Chen; Hong-Mei Jia; Zhong-Mei Zou
Journal:  J Antibiot (Tokyo)       Date:  2017-03-01       Impact factor: 2.649

2.  New azaphilones, seco-chaetomugilins A and D, produced by a marine-fish-derived Chaetomium globosum.

Authors:  Takeshi Yamada; Yasuhide Muroga; Reiko Tanaka
Journal:  Mar Drugs       Date:  2009-06-16       Impact factor: 5.118

3.  Identification and characterization of the chaetoviridin and chaetomugilin gene cluster in Chaetomium globosum reveal dual functions of an iterative highly-reducing polyketide synthase.

Authors:  Jaclyn M Winter; Michio Sato; Satoru Sugimoto; Grace Chiou; Neil K Garg; Yi Tang; Kenji Watanabe
Journal:  J Am Chem Soc       Date:  2012-10-19       Impact factor: 15.419

4.  Chaetoglobosins and azaphilones produced by Canadian strains of Chaetomium globosum isolated from the indoor environment.

Authors:  David R McMullin; Mark W Sumarah; J David Miller
Journal:  Mycotoxin Res       Date:  2012-10-17       Impact factor: 3.833

5.  Investigation of biological activity of soil fungal extracts and LC/MS-QTOF based metabolite profiling.

Authors:  Afrah E Mohammed; Hana Sonbol; Suaad Saleh Alwakeel; Modhi O Alotaibi; Sohailah Alotaibi; Nouf Alothman; Rasha Saad Suliman; Hanadi Talal Ahmedah; Rizwan Ali
Journal:  Sci Rep       Date:  2021-02-26       Impact factor: 4.379

6.  Two phytotoxic azaphilone derivatives from Chaetomium globosum, a fungal endophyte isolated from Amaranthus viridis leaves.

Authors:  K G Nelum P Piyasena; W A R T Wickramarachchi; N Savitri Kumar; Lalith Jayasinghe; Yoshinori Fujimoto
Journal:  Mycology       Date:  2015-09-22

7.  3,4-dihydroxyphenyl acetic acid and (+)-epoxydon isolated from marine algae-derived microorganisms induce down regulation of epidermal growth factor activated mitogenic signaling cascade in Hela cells.

Authors:  Mi Jeong Jo; Seong Ja Bae; Byeng Wha Son; Chi Yeon Kim; Gun Do Kim
Journal:  Cancer Cell Int       Date:  2013-05-25       Impact factor: 5.722

8.  Genome mining of a fungal endophyte of Taxus yunnanensis (Chinese yew) leads to the discovery of a novel azaphilone polyketide, lijiquinone.

Authors:  Jesse W Cain; Kristin I Miller; John A Kalaitzis; Rocky Chau; Brett A Neilan
Journal:  Microb Biotechnol       Date:  2020-04-12       Impact factor: 5.813

Review 9.  Anticancer and antifungal compounds from Aspergillus, Penicillium and other filamentous fungi.

Authors:  Tanja Thorskov Bladt; Jens Christian Frisvad; Peter Boldsen Knudsen; Thomas Ostenfeld Larsen
Journal:  Molecules       Date:  2013-09-13       Impact factor: 4.411

10.  Azaphilones from the Marine Sponge-Derived Fungus Penicillium sclerotiorum OUCMDZ-3839.

Authors:  Qian Jia; Yuqi Du; Chen Wang; Yi Wang; Tonghan Zhu; Weiming Zhu
Journal:  Mar Drugs       Date:  2019-04-30       Impact factor: 5.118
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