| Literature DB >> 19168355 |
Inga Cikotiene1, Egidijus Kazlauskas, Jurgita Matuliene, Vilma Michailoviene, Jolanta Torresan, Jelena Jachno, Daumantas Matulis.
Abstract
A series of 5-aryl-4-(5-substituted-2,4-dihydroxyphenyl)-1,2,3-thiadiazoles were synthesized and their binding to several constructs of human Hsp90 chaperone measured by isothermal titration calorimetry (ITC). The most potent compound bound Hsp90 with the dissociation constant of about 5 nM.Entities:
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Year: 2009 PMID： 19168355 DOI： 10.1016/j.bmcl.2009.01.003
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823