| Literature DB >> 19168354 |
Philip A MacFaul1, Andrew D Morley, James J Crawford.
Abstract
A quantitative assay involving the reaction of nitriles with glutathione and cysteine has been used as a simple in vitro screen to assess potential toxicity risk of candidate compounds in drug discovery. Studies have indicated that, when benchmarked with selected compounds, the reaction of the nitriles with glutathione can provide a useful tool for deciding whether or not to progress compounds in the absence of radiolabelling studies.Entities:
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Year: 2009 PMID： 19168354 DOI： 10.1016/j.bmcl.2008.12.105
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823