| Literature DB >> 19168278 |
Tomoko Kayashima1, Masaharu Mori, Hiromi Yoshida, Yoshiyuki Mizushina, Kiminori Matsubara.
Abstract
Angiogenesis inhibitors are beneficial for the prevention and treatment of angiogenesis-dependent diseases including cancer. Vitamin K2 and K3, which are naphthoquinone derivatives, inhibit angiogenesis. We examined the anti-cancer and anti-angiogenic effects of naphthoquinones and its structurally related compounds. Among these 13 compounds, 1,4-naphthoquinone strongly inhibited both human colon cancer cell (HCT116) growth and angiogenesis. To clarify the anti-angiogenic mechanism, the effects of 1,4-naphthoquinone on human umbilical vein endothelial cell (HUVEC) tube formation, proliferation and chemotaxis were examined. Consequently, 1,4-naphthoquinone inhibited HUVEC functions. These results suggest that 1,4-naphthoquinone may be useful to cancer therapy.Entities:
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Year: 2009 PMID： 19168278 DOI： 10.1016/j.canlet.2008.12.020
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679