Literature DB >> 1916819

An 18-locus linkage map of the pericentromeric region of the human X chromosome: genetic framework for mapping X-linked disorders.

M M Mahtani1, R G Lafrenière, T A Kruse, H F Willard.   

Abstract

We report a high-resolution genetic linkage map of the region Xp11.4 to Xq13.3, spanning the centromere of the X chromosome and encompassing approximately 30 cM. This 18-locus map is composed of 11 intervals that are spaced on average about 3 cM apart. Markers incorporated into the map together detect 19 distinct polymorphisms and include five genes (TIMP, SYP, AR, CCG1, PGK1), the OATL1 cluster, the hypervariable locus DXS255, the centromeric locus DXZ1, and 10 other anonymous DNA segments. Given that this map spans roughly one-fifth of the length of the X chromosome and includes many loci currently used in both diagnosis and mapping of X-linked disorders, it should be useful for genetic counseling and for guiding efforts to clone disease genes in this region.

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Year:  1991        PMID： 1916819     DOI： 10.1016/0888-7543(91)90172-b

Source DB:  PubMed          Journal:  Genomics        ISSN： 0888-7543            Impact factor:   5.736


  12 in total

1.  Physical mapping in the region of human Xq12-21.1 using pulsed field gel electrophoresis.

Authors:  A M Jones; S Malcolm; R J Levinsky; C Kinnon
Journal:  Hum Genet       Date:  1993-06       Impact factor: 4.132

2.  Refinement of linkage of human severe combined immunodeficiency (SCIDX1) to polymorphic markers in Xq13.

Authors:  J M Puck; M E Conley; L C Bailey
Journal:  Am J Hum Genet       Date:  1993-07       Impact factor: 11.025

3.  Linkage analysis of Norrie disease with an X-chromosomal ornithine aminotransferase locus.

Authors:  J B Bateman; T L Kojis; R M Cantor; C Heinzmann; J T Ngo; M A Spence; G Inana; J D Kivlin; D Curtis; R S Sparkes
Journal:  Trans Am Ophthalmol Soc       Date:  1993

4.  Linkage of Wiskott-Aldrich syndrome with three marker loci, DXS426, SYP and TFE3, which map to the Xp11.3-p11.22 region.

Authors:  S M Cremin; W L Greer; R Bodok-Nutzati; M Schwartz; M Peacocke; K A Siminovitch
Journal:  Hum Genet       Date:  1993-10-01       Impact factor: 4.132

5.  Heterogeneity analysis in 40 X-linked retinitis pigmentosa families.

Authors:  P W Teague; M A Aldred; M Jay; M Dempster; C Harrison; A D Carothers; L J Hardwick; H J Evans; L Strain; D J Brock
Journal:  Am J Hum Genet       Date:  1994-07       Impact factor: 11.025

6.  Refined genetic mapping of X-linked Charcot-Marie-Tooth neuropathy.

Authors:  P R Fain; D F Barker; P F Chance
Journal:  Am J Hum Genet       Date:  1994-02       Impact factor: 11.025

7.  High-resolution mapping of the X-linked hypohidrotic ectodermal dysplasia (EDA) locus.

Authors:  J Zonana; M Jones; D Browne; M Litt; P Kramer; H W Becker; N Brockdorff; S Rastan; K P Davies; A Clarke
Journal:  Am J Hum Genet       Date:  1992-11       Impact factor: 11.025

8.  Delineation of the dystonia-parkinsonism syndrome locus in Xq13.

Authors:  M B Graeber; K G Kupke; U Müller
Journal:  Proc Natl Acad Sci U S A       Date:  1992-09-01       Impact factor: 11.205

9.  Clinical reinvestigation and linkage analysis in the family with Episkopi blindness (Norrie disease).

Authors:  G Wolff; A Mayerová; T F Wienker; P Atalianis; P Ioannou; M Warburg
Journal:  J Med Genet       Date:  1992-11       Impact factor: 6.318

10.  The Wiskott-Aldrich syndrome: refinement of the localization on Xp and identification of another closely linked marker locus, OATL1.

Authors:  W L Greer; M Peacocke; K A Siminovitch
Journal:  Hum Genet       Date:  1992-02       Impact factor: 4.132
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