| Literature DB >> 19167885 |
David G Washburn1, Tram H Hoang, Nino Campobasso, Angela Smallwood, Derek J Parks, Christine L Webb, Kelly A Frank, Melanie Nord, Chaya Duraiswami, Christopher Evans, Michael Jaye, Scott K Thompson.
Abstract
A novel series of 1H-indol-1-yl tertiary amine LXR agonists has been designed. Compounds from this series were potent agonists with good rat pharmacokinetic parameters. In addition, the crystal structure of an LXR agonist bound to LXRalpha will be disclosed.Entities:
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Year: 2009 PMID： 19167885 DOI： 10.1016/j.bmcl.2009.01.004
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823