| Literature DB >> 19167884 |
David C Pryde1, Martin Corless, David R Fenwick, Helen J Mason, Blanda C Stammen, Peter T Stephenson, David Ellis, David Bachelor, David Gordon, Christopher G Barber, Anthony Wood, Donald S Middleton, David C Blakemore, Gemma C Parsons, Rachel Eastwood, Michelle Y Platts, Keith Statham, Kerry A Paradowski, Catherine Burt, Wolfgang Klute.
Abstract
The synthesis of a range of novel amine-containing structures and their primary potency as inhibitors of HIV-1 fusion via blocking of the CCR5 receptor is described. The development of the medicinal chemistry strategy and SAR's which led to the identification of the piperidine amide compounds 33 and 36 as excellent leads for further evaluation is described, along with key physicochemical data which highlighted their lead potential.Entities:
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Year: 2009 PMID： 19167884 DOI： 10.1016/j.bmcl.2009.01.012
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823