| Literature DB >> 19167517 |
Ronita Nag1, Michael J Smerdon.
Abstract
DNA acts as a 'workbench' for various nuclear processes that occur inside living cells. In eukaryotic cells, DNA is highly compacted in a structural hierarchy with histones and other proteins into chromatin. This compaction affects DNA structure and coordinates the accessibility to site-specific nuclear factors during DNA processing events. DNA repair is no exception to this general rule and several reviews have appeared recently that discuss this topic in detail [1-3]. Here, we focus on recent findings correlating changes in DNA repair with subtle variations in the chromatin landscape.Mesh:
Substances:
Year: 2009 PMID: 19167517 DOI: 10.1016/j.mrrev.2009.01.002
Source DB: PubMed Journal: Mutat Res ISSN: 0027-5107 Impact factor: 2.433