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Literature DB >> 19167097

Chronic CXCL10 alters neuronal properties in rat hippocampal culture.

Jungsook Cho¹, Thomas E Nelson, Hilda Bajova, Donna L Gruol.

Abstract

The chemokine CXCL10 is expressed in the central nervous system (CNS) during neuroinflammatory conditions. Neurons express CXCR3, the receptor for CXCL10, and neuronal function has been shown to be altered by acute exposure to CXCL10. Little is known about the effects of chronic exposure to CXCL10 on neuronal function. Results from our studies show that chronic exposure of cultured rat hippocampal neurons to CXCL10 results in altered levels of protein for GABA and glutamate receptors and altered synaptic network activity. These effects of CXCL10 may contribute to altered CNS function that occurs in some chronic neuroinflammatory conditions.

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Year: 2009 PMID： 19167097 PMCID： PMC2817940 DOI： 10.1016/j.jneuroim.2008.12.007

Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478

39 in total

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10. Neuronal CXCL10 directs CD8+ T-cell recruitment and control of West Nile virus encephalitis.

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Chronic CXCL10 alters neuronal properties in rat hippocampal culture.

1. Cytokine regulation of CC and CXC chemokine expression by human astrocytes.

2. IP-10/MCP-1 ratio in CSF is an useful diagnostic marker of neuropsychiatric lupus patients.

3. Differential presynaptic localization of metabotropic glutamate receptor subtypes in the rat hippocampus.

4. Cerebrospinal fluid interferon-gamma-inducible protein 10 (IP-10, CXCL10) in HIV-1 infection.

5. CXC chemokine receptors on human oligodendrocytes: implications for multiple sclerosis.

Review 6. Viewing chemokines as a third major system of communication in the brain.

7. Identification of a T cell chemotactic factor in the cerebrospinal fluid of HIV-1-infected individuals as interferon-gamma inducible protein 10.

Review 8. Chemokine receptors in the central nervous system: role in brain inflammation and neurodegenerative diseases.

9. Prolonged expression of interferon-inducible protein-10 in ischemic cortex after permanent occlusion of the middle cerebral artery in rat.

10. Neuronal CXCL10 directs CD8+ T-cell recruitment and control of West Nile virus encephalitis.

1. Ablation of cyclooxygenase-2 in forebrain neurons is neuroprotective and dampens brain inflammation after status epilepticus.

2. Peripheral viral challenge triggers hippocampal production of inflammatory proteins.

3. A broad upregulation of cerebral chemokine genes by peripherally-generated inflammatory mediators.

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5. In-depth characterization of the neuroinflammatory reaction induced by peripheral surgery in an animal model.

6. Peripherally restricted acute phase response to a viral mimic alters hippocampal gene expression.

Review 7. Cerebral Response to Peripheral Challenge with a Viral Mimetic.

8. Microarray analysis of rat sensory ganglia after local inflammation implicates novel cytokines in pain.

9. Programming of neurotoxic cofactor CXCL-10 in HIV-1-associated dementia: abrogation of CXCL-10-induced neuro-glial toxicity in vitro by PKC activator.

Review 10. Immunology primer for neurosurgeons and neurologists part 2: Innate brain immunity.