Literature DB >> 19166846

Regulation of the activity and expression of ERK8 by DNA damage.

Iva V Klevernic1, Niall M B Martin, Philip Cohen.   

Abstract

We have investigated the agonists that activate transfected extracellular signal-regulated kinase 8 (ERK8) in cells, and have found that the most potent activators are hydrogen peroxide, DNA alkylating and cross-linking agents and the poly (ADP-ribose) polymerase inhibitor KU-0058948. The feature shared by all these agents is that they lead to the accumulation of single strand breaks in DNA, suggesting a role for ERK8 in the response to, or repair of, DNA single strand breaks. The DNA alkylating agent MMS also induced the disappearance of endogenous ERK8 by a proteasome-dependent mechanism.

Entities:  

Mesh：

Substances：

Year:  2009        PMID： 19166846     DOI： 10.1016/j.febslet.2009.01.011

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  17 in total

1.  MAPK15 is part of the ULK complex and controls its activity to regulate early phases of the autophagic process.

Authors:  David Colecchia; Francesca Dapporto; Serena Tronnolone; Laura Salvini; Mario Chiariello
Journal:  J Biol Chem       Date:  2018-08-21       Impact factor: 5.157

2.  High-throughput analysis of an RNAi library identifies novel kinase targets in Trypanosoma brucei.

Authors:  Zachary B Mackey; Kyriacos Koupparis; Mari Nishino; James H McKerrow
Journal:  Chem Biol Drug Des       Date:  2011-07-14       Impact factor: 2.817

3.  Differential effects of AMP-activated protein kinase in isolated rat atria subjected to simulated ischemia-reperfusion depending on the energetic substrates available.

Authors:  Romina Hermann; Victoria Evangelina Mestre Cordero; María de Las Mercedes Fernández Pazos; Federico Joaquín Reznik; Débora Elisabet Vélez; Enrique Alberto Savino; María Gabriela Marina Prendes; Alicia Varela
Journal:  Pflugers Arch       Date:  2017-10-14       Impact factor: 3.657

4.  Extracellular signal-regulated kinase 8 (ERK8) controls estrogen-related receptor α (ERRα) cellular localization and inhibits its transcriptional activity.

Authors:  Matteo Rossi; David Colecchia; Carlo Iavarone; Angela Strambi; Federica Piccioni; Arturo Verrotti di Pianella; Mario Chiariello
Journal:  J Biol Chem       Date:  2010-12-28       Impact factor: 5.157

5.  Whole transcriptome analysis reveals an 8-oxoguanine DNA glycosylase-1-driven DNA repair-dependent gene expression linked to essential biological processes.

Authors:  Leopoldo Aguilera-Aguirre; Koa Hosoki; Attila Bacsi; Zsolt Radák; Thomas G Wood; Steven G Widen; Sanjiv Sur; Bill T Ameredes; Alfredo Saavedra-Molina; Allan R Brasier; Xueqing Ba; Istvan Boldogh
Journal:  Free Radic Biol Med       Date:  2015-01-19       Impact factor: 7.376

6.  Dictyostelium Erk2 is an atypical MAPK required for chemotaxis.

Authors:  David J Schwebs; Miao Pan; Nirakar Adhikari; Nick A Kuburich; Tian Jin; Jeffrey A Hadwiger
Journal:  Cell Signal       Date:  2018-03-15       Impact factor: 4.315

7.  EhMAPK, the mitogen-activated protein kinase from Entamoeba histolytica is associated with cell survival.

Authors:  Anupama Sardar Ghosh; Doel Ray; Suman Dutta; Sanghamitra Raha
Journal:  PLoS One       Date:  2010-10-08       Impact factor: 3.240

8.  A chromatin-bound kinase, ERK8, protects genomic integrity by inhibiting HDM2-mediated degradation of the DNA clamp PCNA.

Authors:  Angela L Groehler; Deborah A Lannigan
Journal:  J Cell Biol       Date:  2010-08-23       Impact factor: 10.539

9.  MAPK15/ERK8 stimulates autophagy by interacting with LC3 and GABARAP proteins.

Authors:  David Colecchia; Angela Strambi; Sveva Sanzone; Carlo Iavarone; Matteo Rossi; Claudia Dall'Armi; Federica Piccioni; Arturo Verrotti di Pianella; Mario Chiariello
Journal:  Autophagy       Date:  2012-09-04       Impact factor: 16.016

10.  Structure prediction and validation of the ERK8 kinase domain.

Authors:  Angela Strambi; Mattia Mori; Matteo Rossi; David Colecchia; Fabrizio Manetti; Francesca Carlomagno; Maurizio Botta; Mario Chiariello
Journal:  PLoS One       Date:  2013-01-11       Impact factor: 3.240
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.