Literature DB >> 19165750

Magnolol enhances pentobarbital-induced sleeping behaviors: possible involvement of GABAergic systems.

Hong Ma1, Chung-Soo Kim, Yuan Ma, Sang-Yoon Nam, Dong-Seon Kim, Sung-Sick Woo, Jin-Tae Hong, Ki-Wan Oh.   

Abstract

This study was performed to investigate whether magnolol enhances pentobarbital-induced sleeping behaviors through the GABAergic systems. Magnolol prolonged the sleeping time induced by pentobarbital. In addition, magnolol increased chloride influx in primary cultured cerebellar granule cells. The expression of the GABA(A) receptor alpha-subunit was increased selectively by magnolol, but magnolol had no effect on the abundance of beta- or gamma-subunits. The expression of glutamic acid decarboxylase (GAD) was not influenced by magnolol. It is suggested that magnolol may enhance pentobarbital-induced sleeping behaviors through the activation of GABAergic systems.

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Year:  2009        PMID： 19165750     DOI： 10.1002/ptr.2773

Source DB:  PubMed          Journal:  Phytother Res        ISSN： 0951-418X            Impact factor:   5.878


  8 in total

1.  Magnolol, a major bioactive constituent of the bark of Magnolia officinalis, exerts antiepileptic effects via the GABA/benzodiazepine receptor complex in mice.

Authors:  C R Chen; R Tan; W M Qu; Z Wu; Y Wang; Y Urade; Z L Huang
Journal:  Br J Pharmacol       Date:  2011-11       Impact factor: 8.739

2.  The natural products magnolol and honokiol are positive allosteric modulators of both synaptic and extra-synaptic GABA(A) receptors.

Authors:  Mikhail Alexeev; Denise K Grosenbaugh; David D Mott; Janet L Fisher
Journal:  Neuropharmacology       Date:  2012-03-12       Impact factor: 5.250

3.  Milk Collected at Night Induces Sedative and Anxiolytic-Like Effects and Augments Pentobarbital-Induced Sleeping Behavior in Mice.

Authors:  Irene Joy I dela Peña; Eunyoung Hong; June Bryan de la Peña; Hee Jin Kim; Chrislean Jun Botanas; Ye Seul Hong; Ye Seul Hwang; Byoung Seok Moon; Jae Hoon Cheong
Journal:  J Med Food       Date:  2015-06-04       Impact factor: 2.786

4.  Quinpirole Increases Melatonin-Augmented Pentobarbital Sleep via Cortical ERK, p38 MAPK, and PKC in Mice.

Authors:  Sa-Ik Hong; Seung-Hwan Kwon; Ji-Young Hwang; Shi-Xun Ma; Jee-Yeon Seo; Yong-Hyun Ko; Hyoung-Chun Kim; Seok-Yong Lee; Choon-Gon Jang
Journal:  Biomol Ther (Seoul)       Date:  2016-03-01       Impact factor: 4.634

5.  Administration of Alphas1-Casein Hydrolysate Increases Sleep and Modulates GABAA Receptor Subunit Expression.

Authors:  Taddesse Yayeh; Yea-Hyun Leem; Kyung-Mi Kim; Jae-Chul Jung; Jessica Schwarz; Ki-Wan Oh; Seikwan Oh
Journal:  Biomol Ther (Seoul)       Date:  2018-05-01       Impact factor: 4.634

6.  Screening of sleep assisting drug candidates with a Drosophila model.

Authors:  Yan-Ying Wang; Wei-Wei Ma; I-Feng Peng
Journal:  PLoS One       Date:  2020-07-29       Impact factor: 3.240

7.  Neuropharmacological Assessment of the Hydroethanolic Leaf Extract of Calotropis procera (Ait). R. Br. (Apocynaceae) in Mice.

Authors:  Ernest Obese; Elvis Ofori Ameyaw; Robert Peter Biney; Emmanuel Awintiig Adakudugu; Eric Woode
Journal:  Scientifica (Cairo)       Date:  2021-07-01

8.  Involvement of phosphatase and tensin homolog-induced putative kinase 1/Parkin-mediated autophagy in angiotensin II-induced cardiac hypertrophy in C57BL/6 mice.

Authors:  Gang Fan; Meng-Jie Chen; Jin Wei
Journal:  J Int Med Res       Date:  2019-12-31       Impact factor: 1.671
  8 in total

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