| Literature DB >> 19165615 |
Rodolfo Ocadiz-Delgado1, Alberto Marroquin-Chavira, Ruth Hernandez-Mote, Concepción Valencia, M Eugenia Manjarrez-Zavala, Luis Covarrubias, Patricio Gariglio.
Abstract
Squamous cell carcinoma (SCC) of the oral cavity is one of the most common neoplasms in the world. During the past 2 decades, the role of high-risk human papilloma virus (HR-HPV) has been studied and the data supporting HPV as a one of the causative agents in the development and progression of a sub-set of head and neck squamous cell carcinomas (HNSCC) has accumulated. In order to investigate the role of HR-HPV oncogene expression in early epithelial alterations in vivo, we produced transgenic mice expressing HPV16 early region genes from the promoter of the bovine keratin 6 gene (Tg[bK6-E6/E7]). In this article, we demonstrate that E6/E7 transgene was abundantly expressed and cellular proliferation was increased in the middle tongue epithelia of transgenic mice, and that in the same region young (27 weeks old) Tg[bK6-E6/E7] mice spontaneously developed histological alterations, mainly focal epithelial hyperplasia (FEH).Entities:
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Year: 2009 PMID： 19165615 DOI： 10.1007/s11248-009-9243-6
Source DB: PubMed Journal: Transgenic Res ISSN： 0962-8819 Impact factor: 2.788