PURPOSE: To evaluate the outcome of primary adult optical penetrating keratoplasty (PKP) performed with internationally acquired donor tissue. PATIENTS AND METHODS: A retrospective review was performed of the medical records of every patient 12 years of age or older who underwent PKP for keratoconus, corneal edema, stromal scarring, or stromal dystrophy at King Khaled Eye Specialist Hospital in the Kingdom of Saudi Arabia between January 1, 1997 and December 31, 2001, and for whom a minimum of 3 months' follow-up was available. RESULTS: Of 885 eyes that met the inclusion criteria, there were 453 eyes with keratoconus, 180 eyes with corneal edema, 171 eyes with stromal scarring, and 81 eyes with stromal dystrophy. For the entire group, the probability of graft survival was 96.9% at 1 year, 86.0% at 3 years, and 80.3% at 5 years. The 5-year probability of graft survival was 96.2% for keratoconus, 39.4% for corneal edema, 71.1% for stromal scarring, and 85.2% for stromal dystrophy. Increasing donor age was significantly associated with an increased risk of graft failure on multivariate Cox proportional hazard regression analysis (P = 0.005). Endothelial cell density, death-to-preservation time, and preservation-to-surgery time were not significantly associated with an increased risk of graft failure. CONCLUSIONS: In our patient population, excellent graft survival was achieved utilizing internationally acquired donor tissue for eyes with keratoconus, stromal dystrophy, and stromal scarring, but not for those with corneal edema.
PURPOSE: To evaluate the outcome of primary adult optical penetrating keratoplasty (PKP) performed with internationally acquired donor tissue. PATIENTS AND METHODS: A retrospective review was performed of the medical records of every patient 12 years of age or older who underwent PKP for keratoconus, corneal edema, stromal scarring, or stromal dystrophy at King Khaled Eye Specialist Hospital in the Kingdom of Saudi Arabia between January 1, 1997 and December 31, 2001, and for whom a minimum of 3 months' follow-up was available. RESULTS: Of 885 eyes that met the inclusion criteria, there were 453 eyes with keratoconus, 180 eyes with corneal edema, 171 eyes with stromal scarring, and 81 eyes with stromal dystrophy. For the entire group, the probability of graft survival was 96.9% at 1 year, 86.0% at 3 years, and 80.3% at 5 years. The 5-year probability of graft survival was 96.2% for keratoconus, 39.4% for corneal edema, 71.1% for stromal scarring, and 85.2% for stromal dystrophy. Increasing donor age was significantly associated with an increased risk of graft failure on multivariate Cox proportional hazard regression analysis (P = 0.005). Endothelial cell density, death-to-preservation time, and preservation-to-surgery time were not significantly associated with an increased risk of graft failure. CONCLUSIONS: In our patient population, excellent graft survival was achieved utilizing internationally acquired donor tissue for eyes with keratoconus, stromal dystrophy, and stromal scarring, but not for those with corneal edema.
Authors: Robin L gal; Mariya Dontchev; Roy W Beck; Mark J Mannis; Edward J Holland; Craig Kollman; Steven P Dunn; Ellen L Heck; Jonathan H Lass; Monty M Montoya; Robert L Schultze; R Doyle Stulting; Alan Sugar; Joel Sugar; Bradley Tennant; David D Verdier Journal: Ophthalmology Date: 2008-04 Impact factor: 12.079
Authors: Renato A M Machado; Mark J Mannis; Huck A Mandel; Vahid Feiz; Ivan R Schwab; Wei Wang; Jane-Ling Wang Journal: Cornea Date: 2002-08 Impact factor: 2.651
Authors: Efstathia Kiatos; James J Armstrong; Cindy Ml Hutnik; Stephen M Tsioros; Monali S Malvankar-Mehta; William G Hodge Journal: Clinicoecon Outcomes Res Date: 2017-08-09
Authors: Alice L Yu; Michaela Kaiser; Markus Schaumberger; Elisabeth Messmer; Daniel Kook; Ulrich Welge-Lussen Journal: Clin Ophthalmol Date: 2014-08-28