David M Livermore1, Shazad Mushtaq, Marina Warner, Neil Woodford. 1. Antibiotic Resistance Monitoring and Reference Laboratory, Health Protection Agency Centre for Infections, 61 Colindale Avenue, London NW95EQ, UK. david.livermore@hpa.org.uk
Abstract
BACKGROUND: TR-700 is the active moiety of TR-701 (DA-7157), a new oral/intravenous oxazolidinone prodrug. We examined its activity against linezolid-susceptible and -resistant staphylococci and enterococci. METHODS: MICs were determined by the CLSI agar dilution method. RESULTS: MICs of TR-700 were tightly clustered around 0.5 mg/L for linezolid-susceptible staphylococci and enterococci compared with 2 mg/L for linezolid. MICs for 52 linezolid-resistant isolates were raised, but only exceeded 4 mg/L for two Enterococcus faecium isolates homozygous for the G2576T 23S rRNA mutation and for one with an unknown mechanism of linezolid resistance. CONCLUSIONS: TR-700 is 4- to 16-fold more active than linezolid and overcame most linezolid resistance in vitro.
BACKGROUND: TR-700 is the active moiety of TR-701 (DA-7157), a new oral/intravenous oxazolidinone prodrug. We examined its activity against linezolid-susceptible and -resistant staphylococci and enterococci. METHODS: MICs were determined by the CLSI agar dilution method. RESULTS: MICs of TR-700 were tightly clustered around 0.5 mg/L for linezolid-susceptible staphylococci and enterococci compared with 2 mg/L for linezolid. MICs for 52 linezolid-resistant isolates were raised, but only exceeded 4 mg/L for two Enterococcus faecium isolates homozygous for the G2576T 23S rRNA mutation and for one with an unknown mechanism of linezolid resistance. CONCLUSIONS: TR-700 is 4- to 16-fold more active than linezolid and overcame most linezolid resistance in vitro.
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