UNLABELLED: O-18F-fluoromethyl-D-tyrosine (D-18F-FMT) is a promising novel agent for tumor imaging by PET. The aim of this study was to evaluate the potential of D-18F-FMT and the other conventional ligands used for tumor imaging, namely, 18F-FDG, L-11C-methionine (L-11C-MET), and 3'-deoxy-3'-18F-fluorothymidine (18F-FLT), as a PET ligand for monitoring early responses to radiotherapy in tumor-bearing mice. METHODS: C3H/HeN mice inoculated with murine squamous cell carcinomas were treated with a single dose of x-ray irradiation at 2, 6, 20, or 60 Gy. Tumor uptake of each ligand was examined 1, 3, and 7 d after the irradiation. RESULTS: Tumor uptake of D-18F-FMT was decreased on day 1 after irradiation at 6, 20, or 60 Gy, and the decrease persisted until day 7. Tumor uptake of 18F-FDG was elevated on days 1 and 3 after irradiation at 2, 6, or 20 Gy, followed by a decrease in uptake on day 7 in mice irradiated at 20 or 60 Gy. Decreased tumor uptake of L-11C-MET was observed only on day 3 after the irradiation. Decreased tumor uptake of 18F-FLT was detected on day 1 after irradiation at 2, 6, 20, or 60 Gy; thereafter, the dose-dependent decrease in uptake was no longer seen. Only for D-18F-FMT were significant positive correlations found between ligand uptake at all the time points examined and tumor volume on day 14 after various doses of irradiation. CONCLUSION: The findings suggest that D-18F-FMT is a promising PET ligand for early-phase detection and prediction of the effects of radiation therapy.
UNLABELLED: O-18F-fluoromethyl-D-tyrosine (D-18F-FMT) is a promising novel agent for tumor imaging by PET. The aim of this study was to evaluate the potential of D-18F-FMT and the other conventional ligands used for tumor imaging, namely, 18F-FDG, L-11C-methionine (L-11C-MET), and 3'-deoxy-3'-18F-fluorothymidine (18F-FLT), as a PET ligand for monitoring early responses to radiotherapy in tumor-bearing mice. METHODS: C3H/HeN mice inoculated with murinesquamous cell carcinomas were treated with a single dose of x-ray irradiation at 2, 6, 20, or 60 Gy. Tumor uptake of each ligand was examined 1, 3, and 7 d after the irradiation. RESULTS:Tumor uptake of D-18F-FMT was decreased on day 1 after irradiation at 6, 20, or 60 Gy, and the decrease persisted until day 7. Tumor uptake of 18F-FDG was elevated on days 1 and 3 after irradiation at 2, 6, or 20 Gy, followed by a decrease in uptake on day 7 in mice irradiated at 20 or 60 Gy. Decreased tumor uptake of L-11C-MET was observed only on day 3 after the irradiation. Decreased tumor uptake of 18F-FLT was detected on day 1 after irradiation at 2, 6, 20, or 60 Gy; thereafter, the dose-dependent decrease in uptake was no longer seen. Only for D-18F-FMT were significant positive correlations found between ligand uptake at all the time points examined and tumor volume on day 14 after various doses of irradiation. CONCLUSION: The findings suggest that D-18F-FMT is a promising PET ligand for early-phase detection and prediction of the effects of radiation therapy.
Authors: Bhupesh Parashar; A Gabriella Wernicke; Samuel Rice; Joseph Osborne; Prabhsimranjot Singh; Dattatreyudu Nori; Shankar Vallabhajosula; Stanley Goldsmith; K S Clifford Chao Journal: Discov Med Date: 2012-07 Impact factor: 2.970
Authors: Jan Wedman; Jan Pruim; Jan L N Roodenburg; Gyorgy B Halmos; Johannes A Langedijk; Rudi A J O Dierckx; Bernard F A M van der Laan Journal: Eur Arch Otorhinolaryngol Date: 2012-12-27 Impact factor: 2.503
Authors: Erwin M Wiegman; Jan Pruim; Jan F Ubbels; Harry J M Groen; Johannes A Langendijk; Joachim Widder Journal: Eur J Nucl Med Mol Imaging Date: 2011-01-06 Impact factor: 9.236
Authors: Ioannis Trigonis; Pek Keng Koh; Ben Taylor; Mahbubunnabi Tamal; David Ryder; Mark Earl; Jose Anton-Rodriguez; Kate Haslett; Helen Young; Corinne Faivre-Finn; Fiona Blackhall; Alan Jackson; Marie-Claude Asselin Journal: Eur J Nucl Med Mol Imaging Date: 2014-02-07 Impact factor: 9.236
Authors: Su Jin Jang; Joo Hyun Kang; Yong Jin Lee; Kwang Il Kim; Tae Sup Lee; Jae Gol Choe; Sang Moo Lim Journal: Int J Oncol Date: 2016-02-08 Impact factor: 5.650