Literature DB >> 19164146

Transcriptional signature following inhibition of early-stage cell wall biosynthesis in Staphylococcus aureus.

A J O'Neill1, J A Lindsay, K Gould, J Hinds, I Chopra.   

Abstract

To facilitate mode of action studies on antibacterial inhibitors of early-stage cell wall biosynthesis (CWB), we determined the transcriptional response of Staphylococcus aureus to depletion/inhibition of enzymes in this pathway by DNA microarray analysis. We identified a transcriptional signature distinct from that previously observed following exposure to inhibitors of late-stage CWB.

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Year:  2009        PMID： 19164146      PMCID： PMC2663120          DOI： 10.1128/AAC.01309-08

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


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