Literature DB >> 19163246

High-throughput in vivo genetic and drug screening using femtosecond laser nano-surgery, and microfluidics.

Christopher Rohde1, Cody Gilleland, Chrysanthi Samara, Fei Zeng, Mehmet Fatih Yanik.   

Abstract

We demonstrate microfluidic devices and imaging technologies for high-speed immobilization, cellular resolution imaging, and femtosecond laser micro-surgery of awake small-animals (C. elegans) for high-throughput in vivo genetic and drug screens on neural degeneration and regeneration.

Entities:  

Mesh：

Year:  2008        PMID： 19163246     DOI： 10.1109/IEMBS.2008.4649743

Source DB:  PubMed          Journal:  Conf Proc IEEE Eng Med Biol Soc        ISSN： 1557-170X


  3 in total

1.  Axon regeneration requires coordinate activation of p38 and JNK MAPK pathways.

Authors:  Paola Nix; Naoki Hisamoto; Kunihiro Matsumoto; Michael Bastiani
Journal:  Proc Natl Acad Sci U S A       Date:  2011-06-13       Impact factor: 11.205

2.  A novel high throughput assay for anthelmintic drug screening and resistance diagnosis by real-time monitoring of parasite motility.

Authors:  Michael J Smout; Andrew C Kotze; James S McCarthy; Alex Loukas
Journal:  PLoS Negl Trop Dis       Date:  2010-11-16

3.  The core apoptotic executioner proteins CED-3 and CED-4 promote initiation of neuronal regeneration in Caenorhabditis elegans.

Authors:  Berangere Pinan-Lucarre; Christopher V Gabel; Christopher P Reina; S Elizabeth Hulme; Sergey S Shevkoplyas; R Daniel Slone; Jian Xue; Yujie Qiao; Sarah Weisberg; Kevin Roodhouse; Lin Sun; George M Whitesides; Aravinthan Samuel; Monica Driscoll
Journal:  PLoS Biol       Date:  2012-05-22       Impact factor: 8.029
  3 in total

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