Literature DB >> 19162477

A novel class of allosteric modulators of AMPA/Kainate receptors.

Giuseppe Cannazza1, Krzysztof Jozwiak, Carlo Parenti, Daniela Braghiroli, Marina M Carrozzo, Giulia Puia, Gabriele Losi, Mario Baraldi, Wolfgang Lindner, Irving W Wainer.   

Abstract

The rapid hydrolysis in vivo of IDRA21 to 2-amino-5-chlorobenzensulfonamide has been demonstrated by microdialysis experiments. The IDRA21 metabolite possess in vitro a biological activity similar to that of IDRA21 itself. Taking 2-amino-5-chlorobenzensulfonamide as lead compound, a novel class of AMPAR positive allosteric modulators has been prepared.

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Year:  2008        PMID： 19162477      PMCID： PMC2656388          DOI： 10.1016/j.bmcl.2008.12.094

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  23 in total

1.  Studies of enantiomerization of chiral 3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide type compounds.

Authors:  G Cannazza; D Braghiroli; A Tait; M Baraldi; C Parenti; W Lindner
Journal:  Chirality       Date:  2001-02       Impact factor: 2.437

2.  The effects of IDRA 21, a positive modulator of the AMPA receptor, on delayed matching performance by young and aged rhesus monkeys.

Authors:  Jerry J Buccafusco; Thomas Weiser; Karin Winter; Klaus Klinder; Alvin V Terry
Journal:  Neuropharmacology       Date:  2004-01       Impact factor: 5.250

3.  Mechanism and impact of allosteric AMPA receptor modulation by the ampakine CX546.

Authors:  N Nagarajan; C Quast; A R Boxall; M Shahid; C Rosenmund
Journal:  Neuropharmacology       Date:  2001-11       Impact factor: 5.250

4.  Synthesis of 3,4-dihydro-2H-1,2,4-benzo-thiadiazine 1,1-dioxide derivatives as potential allosteric modulators of AMPA/kainate receptors.

Authors:  Daniela Braghiroli; Giulia Puia; Giuseppe Cannazza; Annalisa Tait; Carlo Parenti; Gabriele Losi; Mario Baraldi
Journal:  J Med Chem       Date:  2002-06-06       Impact factor: 7.446

5.  Modulation of excitatory synaptic transmission by drugs that reduce desensitization at AMPA/kainate receptors.

Authors:  L Vyklicky; D K Patneau; M L Mayer
Journal:  Neuron       Date:  1991-12       Impact factor: 17.173

6.  Heteroarylalkanoic acids with possible antiinflammatory activities, III.

Authors:  C Parenti; L Costantino; M Di Bella; L Raffa; G G Baggio; P Zanoli
Journal:  Arch Pharm (Weinheim)       Date:  1985-10       Impact factor: 3.751

7.  Chiral resolution of the enantiomers of 7-chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide using high-performance liquid chromatography on cellulose-based chiral stationary phases.

Authors:  G Cannazza; D Braghiroli; M Baraldi; C Parenti
Journal:  J Pharm Biomed Anal       Date:  2000-08-01       Impact factor: 3.935

8.  Enantiomerization and hydrolysis of (+/-)-7-chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide by stopped-flow multidimensional high-performance liquid chromatography.

Authors:  Giuseppe Cannazza; Marina M Carrozzo; Daniela Braghiroli; Carlo Parenti
Journal:  J Chromatogr A       Date:  2008-10-01       Impact factor: 4.759

Review 9.  AMPA receptor modulators as cognitive enhancers.

Authors:  Gary Lynch
Journal:  Curr Opin Pharmacol       Date:  2004-02       Impact factor: 5.547

10.  Allosteric potentiation of quisqualate receptors by a nootropic drug aniracetam.

Authors:  I Ito; S Tanabe; A Kohda; H Sugiyama
Journal:  J Physiol       Date:  1990-05       Impact factor: 5.182
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  1 in total

1.  5-Arylbenzothiadiazine Type Compounds as Positive Allosteric Modulators of AMPA/Kainate Receptors.

Authors:  Umberto M Battisti; Krzysztof Jozwiak; Giuseppe Cannazza; Giulia Puia; Gabriella Stocca; Daniela Braghiroli; Carlo Parenti; Livio Brasili; Marina M Carrozzo; Cinzia Citti; Luigino Troisi
Journal:  ACS Med Chem Lett       Date:  2011-11-14       Impact factor: 4.345
  1 in total

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