| Literature DB >> 19162088 |
Cristina B Guzmán1, Kaylan A Graham, Lindsey A Grace, Amy H Moore.
Abstract
Cyclooxygenase (COX)-2 is constitutively expressed in neurons of the hippocampus and neocortex. Therefore, non-steroidal anti-inflammatory drugs (NSAIDs) targeting inflammation-induced COX-2 in the periphery and the central nervous system may also affect cognitive function mediated by basal COX-2 activity. We report that systemic administration of the selective COX-2 inhibitor NS-398 6h prior to behavioral assessment does not influence spatial acquisition or retention in male C57BL/6J mice. However, we observed impaired spatial retention in female mice treated with NS-398, suggesting a sex-dependent role of COX-2 in spatial memory of mice.Entities:
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Year: 2009 PMID： 19162088 PMCID： PMC2693915 DOI： 10.1016/j.bbr.2009.01.005
Source DB: PubMed Journal: Behav Brain Res ISSN： 0166-4328 Impact factor: 3.332