Role of phospholipid in the formation of large aggregates and dissolution of insoluble calcium salts in mode bile solution.

The role of phospholipid in the formation of large aggregates and the dissolution of insoluble calcium salts in bile was studied in mode bile solutions of various lipid compositions. Calcium carbonate was added as an insoluble calcium salt. As the ratio of phospholipid concentration to bile acid increased, the rate of bile acid in the formation of large aggregates increased; total calcium concentration also increased but Ca2+ concentration did not change. Furthermore, a close relationship between the sum of the bile acid and phospholipid concentrations in the large aggregate fraction and the total calcium concentration in model bile solutions was observed. It could be concluded that phospholipid plays a role in dissolution of insoluble calcium salts by promoting the formation of large aggregates in bile.