Literature DB >> 19161320

A versatile approach to beta-amyloid fibril-binding compounds exploiting the Shirakawa/Hayashi protocol for trans-alkene synthesis.

Tri H V Huynh1, Mette Louise H Mantel, Katrine Mikkelsen, Anders T Lindhardt, Niels Chr Nielsen, Daniel Otzen, Troels Skrydstrup.   

Abstract

Application of the Sonogashira coupling reaction followed by a trans-selective alkyne reduction proved highly adaptable for the efficient synthesis of a class of beta-amyloid fibril binding compounds possessing a styrylbenzene motif such as FSB, an FSB dimer, and (19)F-BAY94-9172.

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Year:  2009        PMID: 19161320     DOI: 10.1021/ol8029593

Source DB:  PubMed          Journal:  Org Lett        ISSN: 1523-7052            Impact factor:   6.005


  2 in total

1.  Phenolic bis-styrylbenzenes as β-amyloid binding ligands and free radical scavengers.

Authors:  Daniel P Flaherty; Tomomi Kiyota; Yuxiang Dong; Tsuneya Ikezu; Jonathan L Vennerstrom
Journal:  J Med Chem       Date:  2010-11-01       Impact factor: 7.446

2.  Amyloid-β probes: Review of structure-activity and brain-kinetics relationships.

Authors:  Todd J Eckroat; Abdelrahman S Mayhoub; Sylvie Garneau-Tsodikova
Journal:  Beilstein J Org Chem       Date:  2013-05-28       Impact factor: 2.883

  2 in total

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