| Literature DB >> 19161318 |
Marc Litaudon1, Hadjira Bousserouel, Khalijah Awang, Olivier Nosjean, Marie-Thérèse Martin, Marie Elise Tran Huu Dau, Hamid A Hadi, Jean A Boutin, Thierry Sévenet, Françoise Guéritte.
Abstract
In an effort to find potent inhibitors of the antiapoptotic protein Bcl-xL, a systematic in vitro evaluation was undertaken on 1470 Malaysian plant extracts. The ethyl acetate extract obtained from the bark of Meiogyne cylindrocarpa was selected for its interaction with the Bcl-xL/Bak association. Bioassay-guided purification of this species led to the isolation of two new dimeric sesquiterpenoids (1 and 2) possessing an unprecedented substituted cis-decalin carbon skeleton. Meiogynin A (1) showed the strongest activity with a K(i) of 10.8 +/- 3.1 microM.Entities:
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Year: 2009 PMID： 19161318 DOI： 10.1021/np8006292
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050