PURPOSE: To assess with cardiac magnetic resonance imaging (CMR) the relationship between treatment delay and improvement of regional left ventricular function after primary percutaneous transluminal coronary angioplasty (p-PTCA) for acute myocardial infarction (AMI). MATERIALS AND METHODS: We performed cine- and late-enhancement (LE) CMR in 40 patients with first AMI after restoring TIMI 3 flow with p-PTCA and at a follow-up 4 months later. Infarcted segments were determined from LE images. Regional left ventricular function was quantified from cine-CMR images. Segmentation followed the American Heart Association 17-segments model. Patients were divided into groups with delay <3 hours, 3-6 hours, 6-12 hours, and a delay >12 hours. RESULTS: Segmental wall thickening (SWT) significantly iproved only in segments reperfused within 6 hours (P < 0.001). Follow-up SWT was significantly higher if segments were reperfused early (<3 hours: 74 +/- 4%, 3-6 hours: 57 +/- 4%, 6-12 hours: 48 +/- 7%, <3 to 3-6: P < 0.003, and <3 to 6-12 hours: P < 0.001). The extent of improvement was greater if delay was <3 hours compared to segments with a delay of >3 hours (<3 hours: +21 +/- 3%, 3-6 hours: +8 +/- 4%, 6-12 hours: +6 +/- 3%; <3 hours to 3-6 hours, and 6-12 h, P < 0.02). CONCLUSION: We quantitatively demonstrated that time to p-PTCA treatment significantly influences regional functional recovery of infarcted myocardium at a 4-month follow-up.
PURPOSE: To assess with cardiac magnetic resonance imaging (CMR) the relationship between treatment delay and improvement of regional left ventricular function after primary percutaneous transluminal coronary angioplasty (p-PTCA) for acute myocardial infarction (AMI). MATERIALS AND METHODS: We performed cine- and late-enhancement (LE) CMR in 40 patients with first AMI after restoring TIMI 3 flow with p-PTCA and at a follow-up 4 months later. Infarcted segments were determined from LE images. Regional left ventricular function was quantified from cine-CMR images. Segmentation followed the American Heart Association 17-segments model. Patients were divided into groups with delay <3 hours, 3-6 hours, 6-12 hours, and a delay >12 hours. RESULTS: Segmental wall thickening (SWT) significantly iproved only in segments reperfused within 6 hours (P < 0.001). Follow-up SWT was significantly higher if segments were reperfused early (<3 hours: 74 +/- 4%, 3-6 hours: 57 +/- 4%, 6-12 hours: 48 +/- 7%, <3 to 3-6: P < 0.003, and <3 to 6-12 hours: P < 0.001). The extent of improvement was greater if delay was <3 hours compared to segments with a delay of >3 hours (<3 hours: +21 +/- 3%, 3-6 hours: +8 +/- 4%, 6-12 hours: +6 +/- 3%; <3 hours to 3-6 hours, and 6-12 h, P < 0.02). CONCLUSION: We quantitatively demonstrated that time to p-PTCA treatment significantly influences regional functional recovery of infarcted myocardium at a 4-month follow-up.
Authors: Gert Klug; Sebastian Johannes Reinstadler; Hans-Josef Feistritzer; Christian Kremser; Johannes P Schwaiger; Martin Reindl; Johannes Mair; Silvana Müller; Agnes Mayr; Wolfgang-Michael Franz; Bernhard Metzler Journal: Eur Radiol Date: 2015-09-18 Impact factor: 5.315
Authors: G Klug; S Schenk; J Dörler; A Mayr; B J Haubner; H Alber; V Schächinger; O Pachinger; B Metzler Journal: Clin Res Cardiol Date: 2011-02-11 Impact factor: 5.460
Authors: Gert Klug; Hans-Josef Feistritzer; Sebastian J Reinstadler; Martin Reindl; Christina Tiller; Magdalena Holzknecht; Agnes Mayr; Silvana Müller; Axel Bauer; Bernhard Metzler Journal: Int J Cardiovasc Imaging Date: 2019-11-09 Impact factor: 2.357
Authors: Gert Klug; Agnes Mayr; Johannes Mair; Michael Schocke; Michael Nocker; Thomas Trieb; Werner Jaschke; Otmar Pachinger; Bernhard Metzler Journal: Clin Res Cardiol Date: 2011-01-04 Impact factor: 5.460
Authors: Agnes Mayr; Kathrin Pedarnig; Gert Klug; Michael Schocke; Otmar Pachinger; Werner Jaschke; Bernhard Metzler Journal: Int J Cardiovasc Imaging Date: 2011-10-01 Impact factor: 2.357
Authors: Wolfgang Kromen; Huedayi Korkusuz; Yuecel Korkusuz; Philip Esters; Ralf W Bauer; Frank Huebner; Sebastian Lindemayr; Thomas J Vogl Journal: Int J Cardiovasc Imaging Date: 2012-02-12 Impact factor: 2.357
Authors: Jakob G J Voelkl; Bernhard J Haubner; Christian Kremser; Agnes Mayr; Gert Klug; Alexander Loizides; Silvana Müller; Otmar Pachinger; Michael Schocke; Bernhard Metzler Journal: J Biomed Biotechnol Date: 2010-12-05
Authors: Sebastian J Reinstadler; Martin Reindl; Hans-Josef Feistritzer; Gert Klug; Agnes Mayr; Markus Kofler; Alexander Minh-Duc Tu; Luc Huybrechts; Johannes Mair; Wolfgang-Michael Franz; Bernhard Metzler Journal: Wien Klin Wochenschr Date: 2015-10-06 Impact factor: 1.704