Literature DB >> 19160521

A-94964, novel inhibitor of bacterial translocase I, produced by Streptomyces sp. SANK 60404. II. Physico-chemical properties and structure elucidation.

Yoko Fujita1, Ryo Murakami, Yasunori Muramatsu, Shunichi Miyakoshi, Toshio Takatsu.   

Abstract

In our screening for translocase I inhibitors, we found the novel nucleoside antibiotic, A-94964 in the culture broth of Streptomyces sp. SANK 60404. The structure of A-94964 was elucidated primarily by various NMR studies, including a 1H-31P HMBC experiment. A-94964 has a unique structure which possesses a nucleoside moiety and an N-acylglucosamine moiety connected via a phosphate.

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Year:  2008        PMID: 19160521     DOI: 10.1038/ja.2008.72

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN: 0021-8820            Impact factor:   2.649


  6 in total

Review 1.  A comprehensive review of glycosylated bacterial natural products.

Authors:  Sherif I Elshahawi; Khaled A Shaaban; Madan K Kharel; Jon S Thorson
Journal:  Chem Soc Rev       Date:  2015-11-07       Impact factor: 54.564

Review 2.  Uridine natural products: Challenging targets and inspiration for novel small molecule inhibitors.

Authors:  Christine A Arbour; Barbara Imperiali
Journal:  Bioorg Med Chem       Date:  2020-07-30       Impact factor: 3.641

3.  Amino-group carrier-protein-mediated secondary metabolite biosynthesis in Streptomyces.

Authors:  Fumihito Hasebe; Kenichi Matsuda; Taro Shiraishi; Yushi Futamura; Takeshi Nakano; Takeo Tomita; Ken Ishigami; Hikari Taka; Reiko Mineki; Tsutomu Fujimura; Hiroyuki Osada; Tomohisa Kuzuyama; Makoto Nishiyama
Journal:  Nat Chem Biol       Date:  2016-09-26       Impact factor: 15.040

Review 4.  The biosynthesis of nitrogen-, sulfur-, and high-carbon chain-containing sugars.

Authors:  Chia-I Lin; Reid M McCarty; Hung-wen Liu
Journal:  Chem Soc Rev       Date:  2013-01-25       Impact factor: 54.564

Review 5.  Identification and characterization of enzymes involved in the biosynthesis of pyrimidine nucleoside antibiotics.

Authors:  M McErlean; X Liu; Z Cui; B Gust; S G Van Lanen
Journal:  Nat Prod Rep       Date:  2021-07-21       Impact factor: 15.111

6.  Identification and characterization of bacterial diterpene cyclases that synthesize the cembrane skeleton.

Authors:  Ayuko Meguro; Takeo Tomita; Makoto Nishiyama; Tomohisa Kuzuyama
Journal:  Chembiochem       Date:  2013-02-11       Impact factor: 3.164

  6 in total

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