| Literature DB >> 19160064 |
Cristiana Pistol Tanase1, Simona Dima, Mihaela Mihai, Elena Raducan, Mihnea Ioan Nicolescu, Lucian Albulescu, Bogdan Voiculescu, Traian Dumitrascu, Linda Maria Cruceru, Mircea Leabu, Irinel Popescu, Mihail Eugen Hinescu.
Abstract
The assessment of caveolin-1 (Cav-1) as a marker of tumor aggressiveness in pancreatic ductal adenocarcinoma (PDAC). In this study, we examined the expression of Cav-1 in 34 human PDAC tissue samples and the associated peritumoral tissues by immunohistochemistry and western blot. Additionally, we correlated Cav-1 expression with other tissue (Ki-67, p53) and serum (CA 19-9) tumor markers. In the tumor-derived tissue, both tumor cells and blood vessels expressed Cav-1. In contrast, in peritumoral tissue, Cav-1 expression was confined mainly to blood vessels and was only occasionally expressed in ductal or parenchymal cells. Western blot analysis confirmed the overexpression of Cav-1 in pancreatic tumors compared with peritumoral tissue. Cav-1 expression in tumor tissues was correlated with both the Ki-67 LI (r = 0.95, P < 0.0001) and p53 expression (chi2 = 9.91, P < 0.005). Overexpression of Cav-1 was associated with tumor size, grade and stage and Cav-1 expression in tumors was correlated with an increased serum level of CA 19-9 (r = 0.795, P < 0.001). Based on the results of this study, the inclusion of Cav-1 in a putative panel of biomarkers predicting pancreatic cancer aggressiveness is warranted.Entities:
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Year: 2009 PMID： 19160064 DOI： 10.1007/s10735-008-9209-7
Source DB: PubMed Journal: J Mol Histol ISSN： 1567-2379 Impact factor: 2.611