Literature DB >> 19160051

Ileal mucosal and fecal pancreatitis associated protein levels reflect severity of salmonella infection in rats.

Marleen T J van Ampting1, Wendy Rodenburg, Carolien Vink, Evelien Kramer, Arjan J Schonewille, Jaap Keijer, Roelof van der Meer, Ingeborg M J Bovee-Oudenhoven.   

Abstract

BACKGROUND: Microbial infections induce ileal pancreatitis-associated protein/regenerating gene III (PAP/RegIII) mRNA expression. Despite increasing interest, little is known about the PAP/RegIII protein. Therefore, ileal mucosal PAP/RegIII protein expression, localization, and fecal excretion were studied in rats upon Salmonella infection.
RESULTS: Salmonella infection increased ileal mucosal PAP/RegIII protein levels in enterocytes located at the crypt-villus junction. Increased colonization and translocation of Salmonella was associated with higher ileal mucosal PAP/RegIII levels and secretion of this protein in feces.
CONCLUSIONS: PAP/RegIII protein is increased in enterocytes of the ileal mucosa during Salmonella infection and is associated with infection severity. PAP/RegIII is excreted in feces and might be used as a new and non-invasive infection marker. © Springer Science+Business Media, LLC 2009

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Year:  2009        PMID： 19160051     DOI： 10.1007/s10620-008-0685-0

Source DB:  PubMed          Journal:  Dig Dis Sci        ISSN： 0163-2116            Impact factor:   3.199


  40 in total

Review 1.  First line of defense: the role of the intestinal epithelium as an active component of the mucosal immune system.

Authors:  R S Pitman; R S Blumberg
Journal:  J Gastroenterol       Date:  2000       Impact factor: 7.527

2.  A family of 16-kDa pancreatic secretory stress proteins form highly organized fibrillar structures upon tryptic activation.

Authors:  R Graf; M Schiesser; G A Scheele; K Marquardt; T W Frick; R W Ammann; D Bimmler
Journal:  J Biol Chem       Date:  2001-03-16       Impact factor: 5.157

Review 3.  Bacterial invasion: the paradigms of enteroinvasive pathogens.

Authors:  Pascale Cossart; Philippe J Sansonetti
Journal:  Science       Date:  2004-04-09       Impact factor: 47.728

Review 4.  Bacterial adhesion and entry into host cells.

Authors:  Javier Pizarro-Cerdá; Pascale Cossart
Journal:  Cell       Date:  2006-02-24       Impact factor: 41.582

5.  A rat model for dose-response relationships of Salmonella Enteritidis infection.

Authors:  A H Havelaar; J Garssen; K Takumi; M A Koedam; J B Dufrenne; F M van Leusden; L de La Fonteyne; J T Bousema; J G Vos
Journal:  J Appl Microbiol       Date:  2001-09       Impact factor: 3.772

6.  Dietary calcium phosphate stimulates intestinal lactobacilli and decreases the severity of a salmonella infection in rats.

Authors:  I M Bovee-Oudenhoven; M L Wissink; J T Wouters; R Van der Meer
Journal:  J Nutr       Date:  1999-03       Impact factor: 4.798

7.  Mucosal flora in inflammatory bowel disease.

Authors:  Alexander Swidsinski; Axel Ladhoff; Annelie Pernthaler; Sonja Swidsinski; Vera Loening-Baucke; Marianne Ortner; Jutta Weber; Uwe Hoffmann; Stefan Schreiber; Manfred Dietel; Herbert Lochs
Journal:  Gastroenterology       Date:  2002-01       Impact factor: 22.682

8.  HIP/PAP is an adhesive protein expressed in hepatocarcinoma, normal Paneth, and pancreatic cells.

Authors:  L Christa; F Carnot; M T Simon; F Levavasseur; M G Stinnakre; C Lasserre; D Thepot; B Clement; E Devinoy; C Brechot
Journal:  Am J Physiol       Date:  1996-12

9.  Nitric oxide-derived urinary nitrate as a marker of intestinal bacterial translocation in rats.

Authors:  I M Oudenhoven; H L Klaasen; J A Lapré; A H Weerkamp; R Van der Meer
Journal:  Gastroenterology       Date:  1994-07       Impact factor: 22.682

10.  Arginine-supplemented diets improve survival in gut-derived sepsis and peritonitis by modulating bacterial clearance. The role of nitric oxide.

Authors:  L Gianotti; J W Alexander; T Pyles; R Fukushima
Journal:  Ann Surg       Date:  1993-06       Impact factor: 12.969
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  4 in total

1.  Intestinally secreted C-type lectin Reg3b attenuates salmonellosis but not listeriosis in mice.

Authors:  Marleen T J van Ampting; Linda M P Loonen; Arjan J Schonewille; Irene Konings; Carolien Vink; Juan Iovanna; Mathias Chamaillard; Jan Dekker; Roelof van der Meer; Jerry M Wells; Ingeborg M J Bovee-Oudenhoven
Journal:  Infect Immun       Date:  2012-01-17       Impact factor: 3.441

2.  REG3γ-deficient mice have altered mucus distribution and increased mucosal inflammatory responses to the microbiota and enteric pathogens in the ileum.

Authors:  L M P Loonen; E H Stolte; M T J Jaklofsky; M Meijerink; J Dekker; P van Baarlen; J M Wells
Journal:  Mucosal Immunol       Date:  2013-12-18       Impact factor: 7.313

3.  Mucin Muc2 deficiency and weaning influences the expression of the innate defense genes Reg3β, Reg3γ and angiogenin-4.

Authors:  Nanda Burger-van Paassen; Linda M P Loonen; Janneke Witte-Bouma; Anita M Korteland-van Male; Adrianus C J M de Bruijn; Maria van der Sluis; Peng Lu; Johannes B Van Goudoever; Jerry M Wells; Jan Dekker; Isabelle Van Seuningen; Ingrid B Renes
Journal:  PLoS One       Date:  2012-06-19       Impact factor: 3.240

4.  Compromised mitochondrial fatty acid synthesis in transgenic mice results in defective protein lipoylation and energy disequilibrium.

Authors:  Stuart Smith; Andrzej Witkowski; Ayesha Moghul; Yuko Yoshinaga; Michael Nefedov; Pieter de Jong; Dejiang Feng; Loren Fong; Yiping Tu; Yan Hu; Stephen G Young; Thomas Pham; Carling Cheung; Shana M Katzman; Martin D Brand; Casey L Quinlan; Marcel Fens; Frans Kuypers; Stephanie Misquitta; Stephen M Griffey; Son Tran; Afshin Gharib; Jens Knudsen; Hans Kristian Hannibal-Bach; Grace Wang; Sandra Larkin; Jennifer Thweatt; Saloni Pasta
Journal:  PLoS One       Date:  2012-10-15       Impact factor: 3.240
  4 in total

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