| Literature DB >> 1915889 |
Abstract
A compilation of the pre-mRNA ends of the genes of nuclear encoded mitochondrial proteins resulted in a consensus sequence of the type (T/A)NTTNNNNNTTTNAATAAA. Nucleotide positions +8, +13, +14, +16 and +17 downstream of the AATAAA sequence show also a predominance of nucleotide T. This consensus sequence suggests the importance of the immediate surroundings of the cannonical polyadenylation signal sequence AATAAA on the efficiency of the cleavage and polyadenylation of this specific group of pre-mRNAs.Mesh:
Substances:
Year: 1991 PMID: 1915889 DOI: 10.1016/0014-5793(91)81212-q
Source DB: PubMed Journal: FEBS Lett ISSN: 0014-5793 Impact factor: 4.124