Literature DB >> 1915886

Two proteins act as the IUF1 insulin gene enhancer binding factor.

V Scott1, A R Clark, J C Hutton, K Docherty.   

Abstract

IUF1 is a pancreatic beta cell-specific factor which binds to the sequence 5'-CPyCTAATG-3' (CT box) within the human insulin gene enhancer. Here we show that IUF1 is composed of 2 binding activities that can be separated by DEAE ion exchange chromatography. South Western blot analysis indicates that these distinct binding activities have apparent molecular weights of 115 kDa and 46 kDa.

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Year:  1991        PMID： 1915886     DOI： 10.1016/0014-5793(91)81217-v

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  9 in total

1.  The helix-loop-helix transcription factor USF (upstream stimulating factor) binds to a regulatory sequence of the human insulin gene enhancer.

Authors:  M L Read; A R Clark; K Docherty
Journal:  Biochem J       Date:  1993-10-01       Impact factor: 3.857

Review 2.  Mammalian glucokinase and its gene.

Authors:  P B Iynedjian
Journal:  Biochem J       Date:  1993-07-01       Impact factor: 3.857

Review 3.  Transcription of the insulin gene: towards defining the glucose-sensitive cis-element and trans-acting factors.

Authors:  D Melloul; E Cerasi
Journal:  Diabetologia       Date:  1994-09       Impact factor: 10.122

4.  Glucose modulates the binding of an islet-specific factor to a conserved sequence within the rat I and the human insulin promoters.

Authors:  D Melloul; Y Ben-Neriah; E Cerasi
Journal:  Proc Natl Acad Sci U S A       Date:  1993-05-01       Impact factor: 11.205

5.  Multiple elements in the upstream glucokinase promoter contribute to transcription in insulinoma cells.

Authors:  K D Shelton; A J Franklin; A Khoor; J Beechem; M A Magnuson
Journal:  Mol Cell Biol       Date:  1992-10       Impact factor: 4.272

6.  Transcriptional regulation of the human insulin gene is dependent on the homeodomain protein STF1/IPF1 acting through the CT boxes.

Authors:  H V Petersen; P Serup; J Leonard; B K Michelsen; O D Madsen
Journal:  Proc Natl Acad Sci U S A       Date:  1994-10-25       Impact factor: 11.205

Review 7.  A feat of metabolic proportions: Pdx1 orchestrates islet development and function in the maintenance of glucose homeostasis.

Authors:  Daniella A Babu; Tye G Deering; Raghavendra G Mirmira
Journal:  Mol Genet Metab       Date:  2007-07-30       Impact factor: 4.797

8.  Glucose modulates the binding activity of the beta-cell transcription factor IUF1 in a phosphorylation-dependent manner.

Authors:  W M MacFarlane; M L Read; M Gilligan; I Bujalska; K Docherty
Journal:  Biochem J       Date:  1994-10-15       Impact factor: 3.857

9.  Cooperation between elements of an organ-specific transcriptional enhancer in animals.

Authors:  F Kruse; S D Rose; G H Swift; R E Hammer; R J MacDonald
Journal:  Mol Cell Biol       Date:  1995-08       Impact factor: 4.272
  9 in total

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