PURPOSE: The purpose of this study was to evaluate the clinical results of deep anterior lamellar keratoplasty (DALK) using the Melles technique in granular corneal dystrophy. METHODS: Seven eyes from 5 patients who underwent DALK using Melles technique for granular corneal dystrophy were included in this study. The parameters evaluated included patients' demographics, preoperative and postoperative best spectacle-corrected visual acuities (BSCVAs), and timing and pattern of recurrence. RESULTS: The mean age of the patients was 37 +/- 9.4 years (range 29-46 years) at the time of surgery. The mean length of follow-up (DALK to last visit) was 38.4 +/- 18.6 months (range 10-63 months). The procedure was performed without any major complication in all eyes. Mean preoperative BSCVA was 20/220 (range 20/400 to 20/100), which improved to 20/27 (range 20/30 to 20/25) at 6 months after DALK. Mean BSCVA was 20/50 (range 20/400-20/20) at last follow-up. Simple recurrence occurred in 5 (71%) of 7 eyes. The mean time from surgery to recurrence was 15.6 +/- 1.8 months (range 13-16 months). Clinically significant recurrences occurred 34 +/- 2 months after the procedures in 3 (43%) of 7 eyes. Two (30%) of 7 eyes had no recurrence at all. CONCLUSIONS: Although granular corneal dystrophy is likely to recur after DALK, this technique can restore and preserve useful visual function for a significant period in these patients.
PURPOSE: The purpose of this study was to evaluate the clinical results of deep anterior lamellar keratoplasty (DALK) using the Melles technique in granular corneal dystrophy. METHODS: Seven eyes from 5 patients who underwent DALK using Melles technique for granular corneal dystrophy were included in this study. The parameters evaluated included patients' demographics, preoperative and postoperative best spectacle-corrected visual acuities (BSCVAs), and timing and pattern of recurrence. RESULTS: The mean age of the patients was 37 +/- 9.4 years (range 29-46 years) at the time of surgery. The mean length of follow-up (DALK to last visit) was 38.4 +/- 18.6 months (range 10-63 months). The procedure was performed without any major complication in all eyes. Mean preoperative BSCVA was 20/220 (range 20/400 to 20/100), which improved to 20/27 (range 20/30 to 20/25) at 6 months after DALK. Mean BSCVA was 20/50 (range 20/400-20/20) at last follow-up. Simple recurrence occurred in 5 (71%) of 7 eyes. The mean time from surgery to recurrence was 15.6 +/- 1.8 months (range 13-16 months). Clinically significant recurrences occurred 34 +/- 2 months after the procedures in 3 (43%) of 7 eyes. Two (30%) of 7 eyes had no recurrence at all. CONCLUSIONS: Although granular corneal dystrophy is likely to recur after DALK, this technique can restore and preserve useful visual function for a significant period in these patients.
Authors: Vladimir Lamm; Hidetaka Hara; Alex Mammen; Deepinder Dhaliwal; David K C Cooper Journal: Xenotransplantation Date: 2014-02-21 Impact factor: 3.907