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Literature DB >> 19158490

Tumor endothelial cells have features of adult stem cells.

Abstract

We recently reported that prostate tumor-specific endothelial cells had features of mesenchymal stem cells and could transdifferentiate to form cartilage and bone-like tissues. Plasticity in the tumor vasculature may be related to well-known tumor blood vessel abnormalities and could underlie an intrinsic adaptive mechanism in tumor endothelial cells for circumventing anti-angiogenic strategies.

Entities: Chemical Disease Gene Species

Mesh：

Year: 2009 PMID： 19158490 PMCID： PMC2901174 DOI： 10.4161/cc.8.2.7413

Source DB: PubMed Journal: Cell Cycle ISSN： 1551-4005 Impact factor: 4.534

26 in total

1. Genes expressed in human tumor endothelium.

Authors: B St Croix; C Rago; V Velculescu; G Traverso; K E Romans; E Montgomery; A Lal; G J Riggins; C Lengauer; B Vogelstein; K W Kinzler
Journal: Science Date: 2000-08-18 Impact factor: 47.728

2. Vessel wall-derived endothelial cells rapidly proliferate because they contain a complete hierarchy of endothelial progenitor cells.

Authors: David A Ingram; Laura E Mead; Daniel B Moore; Wayne Woodard; Amy Fenoglio; Mervin C Yoder
Journal: Blood Date: 2004-12-07 Impact factor: 22.113

3. A perivascular origin for mesenchymal stem cells in multiple human organs.

Authors: Mihaela Crisan; Solomon Yap; Louis Casteilla; Chien-Wen Chen; Mirko Corselli; Tea Soon Park; Gabriella Andriolo; Bin Sun; Bo Zheng; Li Zhang; Cyrille Norotte; Pang-Ning Teng; Jeremy Traas; Rebecca Schugar; Bridget M Deasy; Stephen Badylak; Hans-Jörg Buhring; Jean-Paul Giacobino; Lorenza Lazzari; Johnny Huard; Bruno Péault
Journal: Cell Stem Cell Date: 2008-09-11 Impact factor: 24.633

Tumor endothelial cells have features of adult stem cells.

1. Genes expressed in human tumor endothelium.

2. Vessel wall-derived endothelial cells rapidly proliferate because they contain a complete hierarchy of endothelial progenitor cells.

3. A perivascular origin for mesenchymal stem cells in multiple human organs.

Review 4. Vascular calcification: pathobiology of a multifaceted disease.

5. Distinct epigenetic changes in the stromal cells of breast cancers.

Review 6. Normal and pathological breast, the histological basis.

7. CD133+ renal progenitor cells contribute to tumor angiogenesis.

Review 8. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy.

Review 9. Angiogenesis: an organizing principle for drug discovery?

Review 10. The role of endothelial-to-mesenchymal transition in cancer progression.

1. Glucose-activated RUNX2 phosphorylation promotes endothelial cell proliferation and an angiogenic phenotype.

2. A three-dimensional in vitro ovarian cancer coculture model using a high-throughput cell patterning platform.

3. Differential sensitivity of prostate tumor derived endothelial cells to sorafenib and sunitinib.