BACKGROUND AND OBJECTIVES: There is increasing evidence that altered bone metabolism is associated with cardiovascular calcifications in patients with stage 5 chronic kidney disease on hemodialysis (HD). This study was conducted to evaluate the association between bone volume, turnover, and coronary calcifications in HD patients. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: In a cross-sectional study, bone biopsies and multislice computed tomography were performed in 38 HD patients. Bone volume/total volume, activation frequency, and bone formation rate/bone surface were determined by histomorphometry and coronary calcifications were quantified by Agatston scores. RESULTS: Prevalence of low bone turnover was 50% and of low bone volume was 16%. Among the studied traditional cardiovascular risk factors, only age was found to be associated with coronary calcifications. Lower bone volume was a significant risk factor for coronary calcifications during early years of HD, whereas this effect was not observed in patients with dialysis duration >6 yr. Histomorphometric parameters of bone turnover were not associated with coronary calcifications. CONCLUSIONS: Low bone volume is associated with increased coronary calcifications in patients on HD.
BACKGROUND AND OBJECTIVES: There is increasing evidence that altered bone metabolism is associated with cardiovascular calcifications in patients with stage 5 chronic kidney disease on hemodialysis (HD). This study was conducted to evaluate the association between bone volume, turnover, and coronary calcifications in HDpatients. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: In a cross-sectional study, bone biopsies and multislice computed tomography were performed in 38 HDpatients. Bone volume/total volume, activation frequency, and bone formation rate/bone surface were determined by histomorphometry and coronary calcifications were quantified by Agatston scores. RESULTS: Prevalence of low bone turnover was 50% and of low bone volume was 16%. Among the studied traditional cardiovascular risk factors, only age was found to be associated with coronary calcifications. Lower bone volume was a significant risk factor for coronary calcifications during early years of HD, whereas this effect was not observed in patients with dialysis duration >6 yr. Histomorphometric parameters of bone turnover were not associated with coronary calcifications. CONCLUSIONS: Low bone volume is associated with increased coronary calcifications in patients on HD.
Authors: W G Goodman; J Goldin; B D Kuizon; C Yoon; B Gales; D Sider; Y Wang; J Chung; A Emerick; L Greaser; R M Elashoff; I B Salusky Journal: N Engl J Med Date: 2000-05-18 Impact factor: 91.245
Authors: B Peter Sawaya; Rezkalla Butros; Shehzab Naqvi; Zhaopo Geng; Hanna Mawad; Robert Friedler; Paolo Fanti; Marie-Claude Monier-Faugere; Hartmut H Malluche Journal: Kidney Int Date: 2003-08 Impact factor: 10.612
Authors: A Ishani; M Paudel; B C Taylor; E Barrett-Connor; S Jamal; M Canales; M Steffes; H A Fink; E Orwoll; S R Cummings; K E Ensrud Journal: Osteoporos Int Date: 2008-04-05 Impact factor: 4.507
Authors: Hartmut H Malluche; Gustav Blomquist; Marie-Claude Monier-Faugere; Thomas L Cantor; Daniel L Davenport Journal: J Am Soc Nephrol Date: 2015-04-02 Impact factor: 10.121
Authors: L Viaene; G J Behets; S Heye; K Claes; D Monbaliu; J Pirenne; P C D'Haese; P Evenepoel Journal: Osteoporos Int Date: 2015-08-21 Impact factor: 4.507
Authors: Andreas Pasch; Geoffrey A Block; Matthias Bachtler; Edward R Smith; Wilhelm Jahnen-Dechent; Spyridon Arampatzis; Glenn M Chertow; Patrick Parfrey; Xiaoye Ma; Juergen Floege Journal: Clin J Am Soc Nephrol Date: 2016-12-09 Impact factor: 8.237