PURPOSE: To evaluate the feasibility of transarterial prostate embolization for reducing the volume in hormone-induced canine prostate hyperplasia. MATERIALS AND METHODS: Nine beagle dogs were included in this study. Prostate hyperplasia was induced by administering dihydrotestosterone and beta-estradiol. The hormones were given for 12 weeks in group A (n = 4) and 24 weeks in group B (n = 5). Twelve weeks after initiating the hormone treatment, two animals in group A and three in group B underwent prostate embolization with polyvinyl alcohol (PVA) particles. The volume of each prostate was measured three times with magnetic resonance (MR) imaging: once before hormone treatment and at 12 and 24 weeks after initiation of hormone administration. The prostates and bladders were harvested after the third MR study and were grossly and microscopically evaluated. RESULTS: The mean volume of the prostate increased by 156.13% +/- 110.01% in the nine dogs after 12 weeks of hormone administration. In group A (n = 4), the third MR study showed a 67.74% mean decrease in prostate volume in nonembolized dogs and an 81.04% mean decrease in embolized dogs compared with the second MR study. In group B (n = 5), the mean increases in prostate volume between the second and third MR studies were 40.79% in embolized dogs (n = 3) and 75.15% in nonembolized dogs. There was no gross or microscopic change in the bladders except for a focal hemorrhage in one specimen. CONCLUSIONS: Transcatheter arterial embolization is feasible for reducing prostate volume without serious complications in hormone-induced canine prostate hyperplasia.
PURPOSE: To evaluate the feasibility of transarterial prostate embolization for reducing the volume in hormone-induced canineprostate hyperplasia. MATERIALS AND METHODS: Nine beagle dogs were included in this study. Prostate hyperplasia was induced by administering dihydrotestosterone and beta-estradiol. The hormones were given for 12 weeks in group A (n = 4) and 24 weeks in group B (n = 5). Twelve weeks after initiating the hormone treatment, two animals in group A and three in group B underwent prostate embolization with polyvinyl alcohol (PVA) particles. The volume of each prostate was measured three times with magnetic resonance (MR) imaging: once before hormone treatment and at 12 and 24 weeks after initiation of hormone administration. The prostates and bladders were harvested after the third MR study and were grossly and microscopically evaluated. RESULTS: The mean volume of the prostate increased by 156.13% +/- 110.01% in the nine dogs after 12 weeks of hormone administration. In group A (n = 4), the third MR study showed a 67.74% mean decrease in prostate volume in nonembolized dogs and an 81.04% mean decrease in embolized dogs compared with the second MR study. In group B (n = 5), the mean increases in prostate volume between the second and third MR studies were 40.79% in embolized dogs (n = 3) and 75.15% in nonembolized dogs. There was no gross or microscopic change in the bladders except for a focal hemorrhage in one specimen. CONCLUSIONS: Transcatheter arterial embolization is feasible for reducing prostate volume without serious complications in hormone-induced canineprostate hyperplasia.
Authors: Tiago Bilhim; João M Pisco; Andrea Furtado; Diogo Casal; Diogo Pais; Luís Campos Pinheiro; João E G O'Neill Journal: Eur Radiol Date: 2010-11-30 Impact factor: 5.315
Authors: Kyle A Wegner; Hannah Ruetten; Nicholas M Girardi; Chelsea A O'Driscoll; Jaskiran K Sandhu; Anne E Turco; Lisa L Abler; Peiqing Wang; Zunyi Wang; Dale E Bjorling; Rita Malinowski; Richard E Peterson; Douglas W Strand; Paul C Marker; Chad M Vezina Journal: Am J Clin Exp Urol Date: 2021-02-15
Authors: Jin Ho Hwang; Sang Woo Park; Il Soo Chang; Sung Il Jung; Hae Jeong Jeon; Yong Soo Lho; Hyeong Gon Kim; Sung Hyun Paick; Hyoung Keun Park Journal: Biomed Res Int Date: 2017-06-22 Impact factor: 3.411