Literature DB >> 19157883

Synthetic medicinal chemistry of selected antimalarial natural products.

Vipan Kumar1, Aman Mahajan, Kelly Chibale.   

Abstract

Natural products remain a rich source of novel molecular scaffolds for novel antimalarial agents in the fight against malaria. This has been well demonstrated in the case of quinine and artemisinin both of which have served as templates for the development of structurally simpler analogues that either served or continue to serve as effective antimalarials. This review will expound on these two natural products as well as other selected natural products that have served either as antimalarial agents or as potential lead compounds in the development of antimalarial drugs.

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Year:  2008        PMID： 19157883     DOI： 10.1016/j.bmc.2008.10.072

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  10 in total

Review 1.  Alkynoates as Versatile and Powerful Chemical Tools for the Rapid Assembly of Diverse Heterocycles under Transition-Metal Catalysis: Recent Developments and Challenges.

Authors:  Imtiaz Khan; Aliya Ibrar; Sumera Zaib
Journal:  Top Curr Chem (Cham)       Date:  2021-01-05

Review 2.  Merging traditional Chinese medicine with modern drug discovery technologies to find novel drugs and functional foods.

Authors:  Rocky Graziose; Mary Ann Lila; Ilya Raskin
Journal:  Curr Drug Discov Technol       Date:  2010-03

3.  Investigating the activity of quinine analogues versus chloroquine resistant Plasmodium falciparum.

Authors:  Theresa Dinio; Alexander P Gorka; Andrew McGinniss; Paul D Roepe; Jeremy B Morgan
Journal:  Bioorg Med Chem       Date:  2012-03-29       Impact factor: 3.641

4.  Relative to quinine and quinidine, their 9-epimers exhibit decreased cytostatic activity and altered heme binding but similar cytocidal activity versus Plasmodium falciparum.

Authors:  Alexander P Gorka; Katy S Sherlach; Angel C de Dios; Paul D Roepe
Journal:  Antimicrob Agents Chemother       Date:  2012-10-31       Impact factor: 5.191

5.  Discovery and evaluation of thiazinoquinones as anti-protozoal agents.

Authors:  Cary F C Lam; A Norrie Pearce; Shen H Tan; Marcel Kaiser; Brent R Copp
Journal:  Mar Drugs       Date:  2013-09-09       Impact factor: 5.118

Review 6.  Synthetic Strategies for Peroxide Ring Construction in Artemisinin.

Authors:  Vera A Vil'; Ivan A Yaremenko; Alexey I Ilovaisky; Alexander O Terent'ev
Journal:  Molecules       Date:  2017-01-11       Impact factor: 4.411

Review 7.  5,8-Quinolinedione Scaffold as a Promising Moiety of Bioactive Agents.

Authors:  Monika Kadela-Tomanek; Ewa Bębenek; Elwira Chrobak; Stanisław Boryczka
Journal:  Molecules       Date:  2019-11-14       Impact factor: 4.411

8.  New Perspectives on How to Discover Drugs from Herbal Medicines: CAM's Outstanding Contribution to Modern Therapeutics.

Authors:  Si-Yuan Pan; Shu-Feng Zhou; Si-Hua Gao; Zhi-Ling Yu; Shuo-Feng Zhang; Min-Ke Tang; Jian-Ning Sun; Dik-Lung Ma; Yi-Fan Han; Wang-Fun Fong; Kam-Ming Ko
Journal:  Evid Based Complement Alternat Med       Date:  2013-03-24       Impact factor: 2.629

Review 9.  Molecular Farming in Artemisia annua, a Promising Approach to Improve Anti-malarial Drug Production.

Authors:  Giuseppe Pulice; Soraya Pelaz; Luis Matías-Hernández
Journal:  Front Plant Sci       Date:  2016-03-18       Impact factor: 5.753

10.  Antimalarial activity of ultra-short peptides.

Authors:  Lemuel Pérez-Picaso; Benjamín Velasco-Bejarano; A Berenice Aguilar-Guadarrama; Rocío Argotte-Ramos; María Yolanda Rios
Journal:  Molecules       Date:  2009-12-08       Impact factor: 4.411
  10 in total

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