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Literature DB >> 1915765

Effect of vasoactive amines on Weibel-Palade bodies in capillary endothelial cells.

Abstract

The presence and distribution of Weibel-Palade bodies in stomach and colonic mucosal microvessels after the administration of vasoactive amines (serotonin and histamine), the serotonin depletor reserpine, and the von Willebrand factor secretagogue thrombin, was studied by transmission electron microscopy. These agents elevated the number of Weibel-Palade bodies in all microvascular endothelial cells and especially in capillaries. It is concluded that vasoactive amines enhance the synthesis and secretion of large von Willebrand protein multimers by endothelial cells.

Entities: Chemical Disease Gene

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Year: 1991 PMID： 1915765 DOI： 10.1007/bf01922465

Source DB: PubMed Journal: Experientia ISSN： 0014-4754

11 in total

1. Subcellular distribution of reserpine and 5-hydroxytryptamine in blood platelets after treatment with reserpine in vitro and in vivo.

Authors: B F Minter; N Crawford
Journal: Biochem Pharmacol Date: 1974-01-15 Impact factor: 5.858

2. Ultrastructure of "tubular body" in the endothelial cells of the ocular blood vessels.

Authors: H Matsuda; S Sugiura
Journal: Invest Ophthalmol Date: 1970-12

3. Human blood platelet adhesion to artery subendothelium is mediated by factor VIII-Von Willebrand factor bound to the subendothelium.

Authors: K S Sakariassen; P A Bolhuis; J J Sixma
Journal: Nature Date: 1979-06-14 Impact factor: 49.962

10. Differing polarity of the constitutive and regulated secretory pathways for von Willebrand factor in endothelial cells.

Authors: L A Sporn; V J Marder; D D Wagner
Journal: J Cell Biol Date: 1989-04 Impact factor: 10.539

1 in total

1. The fine structure of the human ovarian vein.

Authors: R W Stones; M Turmaine; R W Beard; G Burnstock
Journal: J Anat Date: 1994-10 Impact factor: 2.610

1 in total

Effect of vasoactive amines on Weibel-Palade bodies in capillary endothelial cells.

1. Subcellular distribution of reserpine and 5-hydroxytryptamine in blood platelets after treatment with reserpine in vitro and in vivo.

2. Ultrastructure of "tubular body" in the endothelial cells of the ocular blood vessels.

3. Human blood platelet adhesion to artery subendothelium is mediated by factor VIII-Von Willebrand factor bound to the subendothelium.

4. Immunoelectronmicroscopy: immunogold and immunoperoxidase compared using a new post-embedding system.

5. High resolution light and electron microscopic localization of tubulin with the IGS (immuno gold staining) method.

6. Early endothelial changes in experimental primate atherosclerosis.

7. Weibel-Palade bodies as a marker for neovascularization induced by tumor and rheumatoid angiogenesis factors.

8. Thrombin-mediated release of factor VIII antigen from human umbilical vein endothelial cells in culture.

9. Immunolocalization of von Willebrand protein in Weibel-Palade bodies of human endothelial cells.

10. Differing polarity of the constitutive and regulated secretory pathways for von Willebrand factor in endothelial cells.

1. The fine structure of the human ovarian vein.