| Literature DB >> 19156655 |
Katsunori Tanaka1, Yohei Fujii, Hiroomi Tokimoto, Yasutaka Mori, Shin-ichi Tanaka, Guang-ming Bao, Eric R O Siwu, Aiko Nakayabu, Koichi Fukase.
Abstract
A new solid-phase synthesis of N-linked glycans featuring 1) highly stereoselective beta-mannosylation and microfluidic alpha-sialylation and 2) efficient glycosylation of the N-phenyltrifluoroacetimidate units on JandaJel resin is reported. Reagent concentration effects by a fluorous solvent are effectively applied, and the use of these methods results in the first synthesis of a sialic acid containing complex-type N-glycan on a solid support.Entities:
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Year: 2009 PMID： 19156655 DOI： 10.1002/asia.200800411
Source DB: PubMed Journal: Chem Asian J ISSN： 1861-471X