BACKGROUND: Several epidemiological studies have demonstrated that carotenoid concentrations relate inversely to cardiovascular disease incidence. Thus, we examined the association of circulating carotenoids with hypertension, a major macrovascular disease risk factor. METHODS: Black and White men and women in the Coronary Artery Risk Development in Young Adults Study, aged 18-30 years at recruitment (1985-1986) from four US cities, were investigated over 20 years. At years 0, 7, and 15, we determined the relationships of the sum of four serum carotenoids (alpha-carotene, beta-carotene, lutein/zeaxanthin, cryptoxanthin) and of lycopene with incident hypertension using proportional hazards regression models. RESULTS: In 4412 participants, year 0 sum of four carotenoids was significantly inversely associated with 20-year hypertension incidence after adjustment for baseline systolic blood pressure and other confounding factors (relative hazard per SD increase of sum of four carotenoids: 0.91; 95% confidence interval = 0.84-0.99). The inverse relationships persisted in time-dependent models updating year 0 sum of four carotenoids with year 7 and year 15 values (relative hazard per SD increase of sum of four carotenoids: 0.84; 95% confidence interval = 0.77-0.92). Lycopene was unrelated to hypertension in any model. CONCLUSION: Those individuals with higher concentrations of sum of carotenoids, not including lycopene, generally had lower risk for future hypertension.
BACKGROUND: Several epidemiological studies have demonstrated that carotenoid concentrations relate inversely to cardiovascular disease incidence. Thus, we examined the association of circulating carotenoids with hypertension, a major macrovascular disease risk factor. METHODS: Black and White men and women in the Coronary Artery Risk Development in Young Adults Study, aged 18-30 years at recruitment (1985-1986) from four US cities, were investigated over 20 years. At years 0, 7, and 15, we determined the relationships of the sum of four serum carotenoids (alpha-carotene, beta-carotene, lutein/zeaxanthin, cryptoxanthin) and of lycopene with incident hypertension using proportional hazards regression models. RESULTS: In 4412 participants, year 0 sum of four carotenoids was significantly inversely associated with 20-year hypertension incidence after adjustment for baseline systolic blood pressure and other confounding factors (relative hazard per SD increase of sum of four carotenoids: 0.91; 95% confidence interval = 0.84-0.99). The inverse relationships persisted in time-dependent models updating year 0 sum of four carotenoids with year 7 and year 15 values (relative hazard per SD increase of sum of four carotenoids: 0.84; 95% confidence interval = 0.77-0.92). Lycopene was unrelated to hypertension in any model. CONCLUSION: Those individuals with higher concentrations of sum of carotenoids, not including lycopene, generally had lower risk for future hypertension.
Authors: C Iribarren; A R Folsom; D R Jacobs; M D Gross; J D Belcher; J H Eckfeldt Journal: Arterioscler Thromb Vasc Biol Date: 1997-06 Impact factor: 8.311
Authors: Patricia M Kearney; Megan Whelton; Kristi Reynolds; Paul Muntner; Paul K Whelton; Jiang He Journal: Lancet Date: 2005 Jan 15-21 Impact factor: 79.321
Authors: Lyn M Steffen; Candyce H Kroenke; Xinhua Yu; Mark A Pereira; Martha L Slattery; Linda Van Horn; Myron D Gross; David R Jacobs Journal: Am J Clin Nutr Date: 2005-12 Impact factor: 7.045
Authors: L J Appel; T J Moore; E Obarzanek; W M Vollmer; L P Svetkey; F M Sacks; G A Bray; T M Vogt; J A Cutler; M M Windhauser; P H Lin; N Karanja Journal: N Engl J Med Date: 1997-04-17 Impact factor: 91.245
Authors: G D Friedman; G R Cutter; R P Donahue; G H Hughes; S B Hulley; D R Jacobs; K Liu; P J Savage Journal: J Clin Epidemiol Date: 1988 Impact factor: 6.437
Authors: Emily Taylor Nuss; Ashley R Valentine; Zhumin Zhang; HuiChuan Jennifer Lai; Sherry A Tanumihardjo Journal: Exp Biol Med (Maywood) Date: 2017-04-25
Authors: Michelle D Shardell; Dawn E Alley; Gregory E Hicks; Samer S El-Kamary; Ram R Miller; Richard D Semba; Luigi Ferrucci Journal: Nutr Res Date: 2011-03 Impact factor: 3.315
Authors: Deborah A Levine; Cora E Lewis; O Dale Williams; Monika M Safford; Kiang Liu; David A Calhoun; Yongin Kim; David R Jacobs; Catarina I Kiefe Journal: Hypertension Date: 2010-12-06 Impact factor: 10.190
Authors: Mercedes R Carnethon; Natalie S Evans; Timothy S Church; Cora E Lewis; Pamela J Schreiner; David R Jacobs; Barbara Sternfeld; Stephen Sidney Journal: Hypertension Date: 2010-06-01 Impact factor: 10.190
Authors: April P Carson; Cora E Lewis; David R Jacobs; Carmen A Peralta; Lyn M Steffen; Julie K Bower; Sharina D Person; Paul Muntner Journal: Hypertension Date: 2013-09-16 Impact factor: 10.190
Authors: Michael P Bancks; Mercedes R Carnethon; David R Jacobs; Lenore J Launer; Jared P Reis; Pamela J Schreiner; Ravi V Shah; Stephen Sidney; Kristine Yaffe; Yuichiro Yano; Norrina B Allen Journal: Diabetes Care Date: 2018-10-10 Impact factor: 19.112